scholarly journals Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors

Oncotarget ◽  
2012 ◽  
Vol 3 (11) ◽  
pp. 1320-1334 ◽  
Author(s):  
Robert Callahan ◽  
Uma Mudunuri ◽  
Sharon Bargo ◽  
Ahmed Raafat ◽  
David McCurdy ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumors ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Mouse Mammary Tumors ◽  
Tumor Virus ◽  
Human Mammary Tumors

Studies of Mouse Mammary Tumor Virus by Ferritin-labeled Antibody

1970 ◽  
Vol 28 ◽  
pp. 170-171
Author(s):  
T. Kodama ◽  
W. C. Williams ◽  
R. L. Hales ◽  
L. Dmochowski
Keyword(s):  
Virus Type ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Leukemia Virus ◽  
Mammary Tumors ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Mouse Mammary Tumors ◽  
Mouse Leukemia Virus ◽  
Tumor Virus

Morphological, biological, and immunological studies indicate a possible interrelationship between mouse mammary tumor virus and leukemia virus in the development of mouse mammary tumors. Electron microscope studies have shown the presence of both mouse mammary tumor virus (type B) particles and mouse leukemia virus (type C) particles in mouse milk, in tissues, and in tissue cultures from spontaneous and induced mouse mammary tumors (Dmochowski, L., et; al.: Carcinogenesis, A Broad Critique, Williams and Wilkins Co., Baltimore, p.211, 1967;., Dmochowski, L., et al.: J.Nat. Cancer Inst., 40:1339, 1968).

scholarly journals A New Common Integration Site, Int7, for the Mouse Mammary Tumor Virus in Mouse Mammary Tumors Identifies a Gene Whose Product Has Furin-Like and Thrombospondin-Like Sequences

2005 ◽  
Vol 79 (15) ◽  
pp. 10093-10096 ◽  
Author(s):  
William Lowther ◽  
Korah Wiley ◽  
Gilbert H. Smith ◽  
Robert Callahan
Keyword(s):  
Mammary Tumor ◽  
Transcription Initiation ◽  
Mouse Mammary Tumor Virus ◽  
Integration Site ◽  
Mammary Tumors ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Mouse Mammary Tumors ◽  
Tumor Virus ◽  
Common Integration Site

ABSTRACT A novel common integration site for the mouse mammary tumor virus (MMTV) was identified (designated Int7) in five independently arising mouse mammary tumors. The insertion sites all cluster within a 1-kb region that is 2 to 3 kb 5′ of the transcription initiation site of a gene, 2610028F08RIK, whose gene product contains furin-like and thrombospondin-like sequences. Expression of Int7 is normally very low or silent during various stages of mammary gland development, but MMTV integration at this site results in the activation of high steady-state levels of expression of the gene. These five tumors were also found to have two or three additional viral insertions, which in each case occurred flanking a member of either the Wnt and/or FGF gene family. Reverse transcriptase PCR results demonstrated that each of the viral insertions led to elevated expression of the presumed target flanking genes.

Selective amplification of mouse mammary tumor virus in mammary tumors of GR mice.

1980 ◽  
Vol 36 (1) ◽  
pp. 109-114 ◽  
Author(s):  
T G Fanning ◽  
J P Puma ◽  
R D Cardiff
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumors ◽  
Mammary Tumor Virus ◽  
Selective Amplification ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

scholarly journals Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4

1997 ◽  
Vol 94 (16) ◽  
pp. 8664-8669 ◽  
Author(s):  
E. H. Radany ◽  
K. Hong ◽  
S. Kesharvarzi ◽  
E. S. Lander ◽  
J. M. Bishop
Keyword(s):  
Mouse Chromosome ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumors ◽  
Allelic Loss ◽  
Chromosome 4 ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

scholarly journals Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2- mouse strain.

1980 ◽  
Vol 152 (3) ◽  
pp. 712-719 ◽  
Author(s):  
R Nusse ◽  
J de Moes ◽  
J Hilkens ◽  
R van Nie
Keyword(s):  
Mammary Tumor ◽  
Mouse Strain ◽  
Mouse Mammary Tumor Virus ◽  
Mammary Tumors ◽  
Viral Envelope ◽  
Chromosome 11 ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Dominant Feature ◽  
Tumor Virus

The GR/Mtv-2- mouse strain is congenic to the GR strain but lacks the Mtv-2 gene for high amounts of mouse mammary tumor virus (MMTV) virion particles in the milk and early mammary tumors. With a sensitive competition radioimmunoassay for individual viral proteins of MMTV, substantial amounts of the gag proteins p27 and p10 could still be detected in extracts of the mammary glands of GR/Mtv-2- mice, but essentially no viral envelope antigens. The genetic transmission of the MMTV gag expression in the GR/Mtv-2- strain was investigated. In a cross with the virus-negative BALB/c strain, the MMTV p27 expression behaved as a dominant feature. Double backcross analysis proved that the p27 expression was governed by a single gene located on chromosome 11, cloe to the Es-3 locus. The gene was thereby not allelic to any of the previously described MMTV induction genes, Mtv-1 and Mtv-2, and is therefore called Mtv-3. It is concluded that the total MMTV expression in the GR strain is under control of two separate loci, Mtv-2 on chromosome 18, inducing high levels of complete virus particles and also early mammary tumors; and Mtv-3 on chromosome 11, coding for partial MMTV expression.

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