scholarly journals Positive inotroPic agents for treatment of acute heart failure

2013 ◽  
Vol 6 (4) ◽  
pp. 79-85
Author(s):  
Svetlana D. MayanSkaya ◽  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Inotropic Agents ◽  
Positive Inotropic Agents

Investigational Positive Inotropic Agents for Acute Heart Failure

2009 ◽  
Vol 9 (3) ◽  
pp. 193-205 ◽  
Author(s):  
Juan Tamargo ◽  
Ricardo Caballero ◽  
Ricardo Gomez ◽  
Adriana Barana ◽  
Irene Amoros ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Inotropic Agents ◽  
Positive Inotropic Agents

New Positive Inotropic Agents in the Treatment of Congestive Heart Failure

1986 ◽  
Vol 314 (6) ◽  
pp. 349-358 ◽  
Author(s):  
Wilson S. Colucci ◽  
Richard F. Wright ◽  
Eugene Braunwald
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Inotropic Agents ◽  
Positive Inotropic Agents

Positive inotropes

2018 ◽  
Author(s):  
Mattia Arrigo ◽  
Alexandre Mebazaa
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Mechanisms Of Action ◽  
Inotropic Agents ◽  
Organ Perfusion ◽  
Cardiac Myosin ◽  
Inappropriate Use ◽  
Calcium Sensitizers ◽  
Phosphodiesterase Iii Inhibitors ◽  
Phosphodiesterase Iii

Inotropic agents are substances used to improve cardiac output and end-organ perfusion in severe forms of acute heart failure. However, inappropriate use of inotropic agents may be associated with severe adverse effects and death. Despite clear indications to restrict their use to acute heart failure patients presenting with signs of end-organ hypoperfusion, the current use of inotropes is very frequent and often unnecessary. This chapter reviews mechanisms of action of current and future inotropes (including catecholamines, phosphodiesterase-III inhibitors, calcium sensitizers, cardiac myosin activators, and istaroxime) and discusses their clinical use in acute heart failure.

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