scholarly journals Predictors of Transient Congenital Primary Hypothyroidism: Data from the German Registry for Congenital Hypothyroidism (AQUAPE "HypoDok")

2021 ◽  
Author(s):  
Nicola Matejek ◽  
Sascha R. Tittel ◽  
Holger Haberland ◽  
Tilman Rohrer ◽  
Eva-Maria Busemann ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Receiver Operating Characteristic ◽  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Primary Hypothyroidism ◽  
Associated Malformations ◽  
German Registry ◽  
Receiver Operating

Abstract Neonatal screening for congenital primary hypothyroidism (CH) may not distinguish between transient (TCH) and permanent dysfunction (PCH), causing potential overtreatment and concerns in affected families. To specify the indication for interruption of therapy we analysed the German registry "HypoDok" for infants with CH, which oversees 1,625 patients from 49 participating centres in Germany and Austria from 1997 until today. 357 Patients with a thyroid gland in loco typico were identified and retrospectively grouped according to cessation (TCH n=24) or continuation (PCH n=333) of L-Thyroxine (L-T4) treatment at 2 years of age. The receiver operating characteristic (ROC) analysis was performed to identify cut-offs predicting TCH by screening TSH concentrations and L-T4 dosages. Gestational ages, birth weights and prevalence of associated malformations were comparable in both groups. The cut-off screening TSH concentration was 73 mU/L. The cut-off daily L-T4 dosage at 1 year was 3.1 µg/kg (90% sensitivity, 63% specificity; 36 µg/d) and at 2 years of age 2.95 µg/kg (91% sensitivity, 59% specificity; 40 µg/d). At 2 years of age, specificity (71%) increased when these both parameters were considered together. Conclusion: The decision to continue or cease L-T4 treatment at 2 years of age in CH patients diagnosed in neonatal screening may be based on their screening TSH concentrations and individual L-T4 dosages at 1 and 2 years of age. Thus, TCH and PCH may be distinguished; overtreatment avoided, and affected families reassured.

scholarly journals Predictors of transient congenital primary hypothyroidism: data from the German registry for congenital hypothyroidism (AQUAPE “HypoDok”)

2021 ◽  
Author(s):  
Nicola Matejek ◽  
Sascha R. Tittel ◽  
Holger Haberland ◽  
Tilman Rohrer ◽  
Eva-Maria Busemann ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Congenital Hypothyroidism ◽  
Neonatal Screening ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Primary Hypothyroidism ◽  
Treatment Withdrawal ◽  
Associated Malformations ◽  
German Registry ◽  
Higher Sensitivity

AbstractNeonatal screening for congenital primary hypothyroidism (CH) may not distinguish between transient (TCH) and permanent dysfunction (PCH), causing potential overtreatment and concerns in affected families. To specify the indication for interruption of therapy, we analysed the German registry “HypoDok” for infants with CH, which oversees 1625 patients from 49 participating centres in Germany and Austria from 1997 until today. A total of 357 patients with a thyroid gland in loco typico were identified and retrospectively grouped according to cessation (TCH, n = 24) or continuation (PCH, n = 333) of l-thyroxine (l-T4) treatment at 2 years of age. The receiver operating characteristic (ROC) analysis was performed to identify cutoffs predicting TCH by screening TSH concentrations and l-T4 dosages. Gestational ages, birth weights and prevalence of associated malformations were comparable in both groups. The cutoff screening TSH concentration was 73 mU/L. The cutoff daily l-T4 dosage at 1 year was 3.1 μg/kg (90% sensitivity, 63% specificity; 36 μg/day) and at 2 years of age 2.95 μg/kg (91% sensitivity, 59% specificity; 40 μg/day). At 2 years of age, specificity (71%) increased when both of these parameters were considered together.Conclusion: The decision to continue or cease l-T4 treatment at 2 years of age in CH patients diagnosed in neonatal screening may be based on their screening TSH concentrations and individual l-T4 dosages at 1 and 2 years of age. Thus, TCH and PCH may be distinguished; overtreatment avoided; and affected families reassured. What is Known:• The course of congenital primary hypothyroidism may be transient, causing potential overtreatment.• The dose ofl-thyroxine at 1 or 2 years of age may predict a transient course of primary congenital hypothyroidism. What is New:• TSH screening concentration andl-thyroxine dosages at 1 and 2 years of age represent reliable predictors for transient congenital primary hypothyroidism with higher sensitivity and specificity when considered together in order to select eligible patients who qualify for treatment withdrawal.

scholarly journals Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Cheng-Hong Yang ◽  
Sin-Hua Moi ◽  
Li-Yeh Chuang ◽  
Shyng-Shiou F. Yuan ◽  
Ming-Feng Hou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Receiver Operating Characteristic ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Growth Factor Receptor ◽  
Cancer Recurrence ◽  
Breast Cancer Recurrence ◽  
Prognostic Indicators ◽  
Clinicopathologic Characteristics ◽  
Receiver Operating

The interaction between the meiotic recombination 11 homolog A (MRE11) oncoprotein and breast cancer recurrence status remains unclear. The aim of this study was to assess the interaction between MRE11 and clinicopathologic variables in breast cancer. A dataset for 254 subjects with breast cancer (220 nonrecurrent and 34 recurrent) was used in individual and cumulated receiver operating characteristic (ROC) analyses of MRE11 and 12 clinicopathologic variables for predicting breast cancer recurrence. In individual ROC analysis, the area under curve (AUC) for each predictor of breast cancer recurrence was smaller than 0.7. In cumulated ROC analysis, however, the AUC value for each predictor improved. Ten relevant variables in breast cancer recurrence were used to find the optimal prognostic indicators. The presence of any six of the following ten variables had a high (79%) sensitivity and a high (70%) specificity for predicting breast cancer recurrence: tumor size ≥ 2.4 cm, tumor stage II/III, therapy other than hormone therapy, age ≥ 52 years, MRE11 positive cells > 50%, body mass index ≥ 24, lymph node metastasis, positivity for progesterone receptor, positivity for epidermal growth factor receptor, and negativity for estrogen receptor. In conclusion, this study revealed that these 10 clinicopathologic variables are the minimum discriminators needed for optimal discriminant effectiveness in predicting breast cancer recurrence.

scholarly journals Bayesian Sensitivity-Specificity and ROC Analysis for Finding Key Drivers

2021 ◽  
Vol 19 (1) ◽  
pp. 2-15
Author(s):  
Stan Lipovetsky ◽  
Michael W. Conklin
Keyword(s):  
Receiver Operating Characteristic ◽  
Statistical Modeling ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Regression Modeling ◽  
Modeling And Analysis ◽  
Numerical Comparisons ◽  
Key Drivers ◽  
Sensitivity Specificity ◽  
Receiver Operating

Finding key drivers in regression modeling via Bayesian Sensitivity-Specificity and Receiver Operating Characteristic is suggested, and clearly interpretable results are obtained. Numerical comparisons with other techniques show that this methodology can be useful in practical statistical modeling and analysis helping to researchers and managers in making meaningful decisions.

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