Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (5). In Vitro Metabolism and Plasma Protein Binding in Animals and Human.

Hideki FUJINO; Iwao YAMADA; Junji KOJIMA; Masaru HIRANO; Hiroo MATSUMOTO; Michiaki YONEDA

doi:10.2133/dmpk.14.415

Studies on the Metabolic Fate of NK-104, a New Inhibitor of HMG-CoA Reductase. (5). In Vitro Metabolism and Plasma Protein Binding in Animals and Human.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.14.415 ◽

1999 ◽

Vol 14 (6) ◽

pp. 415-424 ◽

Cited By ~ 4

Author(s):

Hideki FUJINO ◽

Iwao YAMADA ◽

Junji KOJIMA ◽

Masaru HIRANO ◽

Hiroo MATSUMOTO ◽

...

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

In Vitro Metabolism ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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Evaluation of oral pharmacokinetics, in vitro metabolism, blood partitioning and plasma protein binding of novel antidiabetic agent, S009-0629 in rats

Drug Development Research ◽

10.1002/ddr.21433 ◽

2018 ◽

Vol 79 (4) ◽

pp. 173-183 ◽

Cited By ~ 1

Author(s):

Guru Raghavendra Valicherla ◽

Kishan Shamjibhai Italiya ◽

Chandra Prakash Gupta ◽

Shachi Mishra ◽

Mohammed Riyazuddin ◽

...

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

In Vitro Metabolism ◽

Antidiabetic Agent ◽

Oral Pharmacokinetics

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Pharmacokinetic properties, in vitro metabolism and plasma protein binding of govaniadine an alkaloid isolated from Corydalis govaniana Wall

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2016.09.003 ◽

2016 ◽

Vol 131 ◽

pp. 464-472 ◽

Cited By ~ 6

Author(s):

Lucas M.M. Marques ◽

Daniel R. Callejon ◽

Larissa G. Pinto ◽

Michel L. de Campos ◽

Anderson R.M. de Oliveira ◽

...

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

In Vitro Metabolism ◽

Pharmacokinetic Properties

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Studies on the metabolic fate of itavastatin, a new inhibitor of HMG-CoA reductase-in vitro metabolism

Atherosclerosis ◽

10.1016/s0021-9150(00)80226-9 ◽

2000 ◽

Vol 151 (1) ◽

pp. 50 ◽

Cited By ~ 2

Author(s):

H Fujino ◽

I Yamada ◽

S Shimada ◽

H Matsumoto ◽

M Yoneda

Keyword(s):

In Vitro Metabolism ◽

Metabolic Fate ◽

Hmg Coa Reductase ◽

Coa Reductase

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A rapid and sensitive bioanalytical LC–MS/MS method for the quantitation of a novel CDK5 inhibitor 20–223 (CP668863) in plasma: Application to in vitro metabolism and plasma protein‐binding studies

Biomedical Chromatography ◽

10.1002/bmc.4859 ◽

2020 ◽

Vol 34 (8) ◽

Cited By ~ 1

Author(s):

Veenu Bala ◽

Yashpal S. Chhonker ◽

Richard L. Sleightholm ◽

Ayrianne J. Crawford ◽

Michael A. Hollingsworth ◽

...

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

In Vitro Metabolism ◽

Binding Studies

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Toxicokinetics and analytical toxicology of the abused opioid U‐48800 — in vitro metabolism, metabolic stability, isozyme mapping, and plasma protein binding

Drug Testing and Analysis ◽

10.1002/dta.2683 ◽

2019 ◽

Vol 11 (10) ◽

pp. 1572-1580 ◽

Cited By ~ 5

Author(s):

Tanja M. Gampfer ◽

Lilian H.J. Richter ◽

Jan Schäper ◽

Lea Wagmann ◽

Markus R. Meyer

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Metabolic Stability ◽

In Vitro Metabolism ◽

Analytical Toxicology

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Metabolic Fate of Clonidine. (IV): Plasma Protein Binding of Clonidine In vitro and In vivo and Transfer to Fetus and Milk in Rats after Subcutaneous Administration of Clonidine.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.11.404 ◽

1996 ◽

Vol 11 (4) ◽

pp. 404-410 ◽

Cited By ~ 1

Author(s):

Tohru YAMAHATA ◽

Yasuo MINAKI ◽

Hitoshi NISHIKAWA ◽

Yoshio ESUMI ◽

Yoshitaka JIN ◽

...

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Subcutaneous Administration ◽

Metabolic Fate

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Studies on the Metabolic Fate of Lamivudine (II): Tissue Distribution, Transfer into Fetus and Milk, Plasma Protein Binding and Distribution to Erythrocytes of Lamivudine in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.12.92 ◽

1997 ◽

Vol 12 (2) ◽

pp. 92-101

Author(s):

Takatoshi TAKUBO ◽

Seiji HIRAYAMA ◽

Takahito MORIYA ◽

Yoshiyuki MINAMIDE ◽

Toshihiro KATO ◽

...

Keyword(s):

Protein Binding ◽

Tissue Distribution ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Metabolic Fate

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Rapid Equilibrium Dialysis (RED): an In-vitro High-Throughput Screening Technique for Plasma Protein Binding using Human and Rat Plasma

Journal of Bioequivalence & Bioavailability ◽

10.4172/jbb.s14-005 ◽

2012 ◽

Vol s14 ◽

Cited By ~ 4

Author(s):

Jitendra Kumar Singh ◽

Anant Solanki

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

High Throughput ◽

Plasma Protein ◽

High Throughput Screening ◽

Equilibrium Dialysis ◽

Rat Plasma ◽

Screening Technique ◽

Rapid Equilibrium

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Potency and plasma protein binding of drugs in vitro—a potentially misleading pair for predicting in vivo efficacious concentrations in humans

Korean Journal of Physiology and Pharmacology ◽

10.4196/kjpp.2019.23.4.231 ◽

2019 ◽

Vol 23 (4) ◽

pp. 231

Author(s):

Dong-Seok Yim

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Protein Binding Of Drugs

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Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models

Toxicology in Vitro ◽

10.1016/j.tiv.2020.105051 ◽

2020 ◽

pp. 105051

Author(s):

Cathy Lester ◽

Nicola J. Hewitt ◽

Ursula Müller-Vieira ◽

Manuela Mayer ◽

Corie Ellison ◽

...

Keyword(s):

Protein Binding ◽

Plasma Protein Binding ◽

Plasma Protein ◽

Branched Chain

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