Combination Therapy of Gefitinib and MiR-30a-5p May Overcome the Acquired Drug Resistance by Regulating PI3K/AKT Pathway in Non-Small Cell Lung Cancer

2019 ◽  
Author(s):  
Fengfeng Wang ◽  
Fei Meng ◽  
S. C. Cesar Wong ◽  
William C. S. Cho ◽  
Lawrence Wing Chi Chan
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Combination Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Akt Pathway ◽  
Small Cell Lung ◽  
Acquired Drug Resistance

scholarly journals Enhanced cohesion promotes chromosome stability and limits acquired drug resistance in non small cell lung cancer

2020 ◽  
Author(s):  
Nicole M Hermance ◽  
Elizabeth A Crowley ◽  
Conor P Herlihy ◽  
Amity L Manning
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Tumor Heterogeneity ◽  
Small Cell ◽  
Tumor Evolution ◽  
Small Cell Lung ◽  
Acquired Drug Resistance

AbstractChromosome instability, or CIN, defined as a high frequency of whole chromosome gains and losses, is prevalent in many solid tumors. CIN has been shown to promote intra-tumor heterogeneity and correspond with tumor aggressiveness, drug resistance and tumor relapse. However, whether CIN promotes the acquisition of genomic changes responsible for drug resistance remain unclear. Here we assess the role of CIN in the acquisition of drug resistance in non small cell lung cancer. We show that impairment of centromeric cohesion underlies the generation of whole chromosome segregation errors and CIN in non small cell lung cancer cells. Further, we demonstrate that centromere-specific enhancement of chromosome cohesion strongly suppresses CIN and reduces intra-tumor heterogeneity. We demonstrate that suppression of CIN has no impact on NSCLC cell proliferation in vitro nor in tumor initiation in mouse xenograft models. However, suppression of CIN alters the timing and molecular mechanism that drive acquired drug resistance. These findings suggest mechanisms to suppress CIN may serve as effective co-therapies to limit tumor evolution and sustain drug response.

scholarly journals Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non–Small Cell Lung Cancer

2015 ◽  
Vol 75 (22) ◽  
pp. 4937-4948 ◽  
Author(s):  
Alexandra B. Lantermann ◽  
Dongshu Chen ◽  
Kaitlin McCutcheon ◽  
Greg Hoffman ◽  
Elizabeth Frias ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Casein Kinase 1 ◽  
Acquired Drug Resistance ◽  
Egfr Mutant ◽  
Casein Kinase 1 Alpha

Abstract B30: Three-dimensional organoid model for acquired drug resistance in non-small cell lung cancer

2018 ◽  
Author(s):  
Navika D. Shukla ◽  
Ameen A. Salahudeen ◽  
Sukhmani K. Padda ◽  
Joel W. Neal ◽  
Heather A. Wakelee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Three Dimensional ◽  
Small Cell ◽  
Small Cell Lung ◽  
Acquired Drug Resistance

scholarly journals FGFRL1 affects chemoresistance of small‐cell lung cancer by modulating the PI3K/Akt pathway via ENO1

2020 ◽  
Vol 24 (3) ◽  
pp. 2123-2134 ◽  
Author(s):  
Rui Chen ◽  
Deyu Li ◽  
Meng Zheng ◽  
Bin Chen ◽  
Ting Wei ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Akt Pathway ◽  
Small Cell Lung

circSNX6 (hsa_circ_0031608) enhances drug resistance of non-small cell lung cancer (NSCLC) via miR-137

2021 ◽  
Vol 567 ◽  
pp. 79-85
Author(s):  
Koujun Zhu ◽  
Jun Zhu ◽  
Jichun Geng ◽  
Yongjian Zhang ◽  
Yan Qin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

Combination Therapy of Radiotherapy and Anti-PD-1/PD-L1 Treatment in Non–Small-cell Lung Cancer: A Mini-review

2018 ◽  
Vol 19 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Shinkichi Takamori ◽  
Gouji Toyokawa ◽  
Kazuki Takada ◽  
Fumihiro Shoji ◽  
Tatsuro Okamoto ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Combination Therapy ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung
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