A Sensitization Of Projection Neurons from Prelimbic Cortex to Paraventricular Nucleus of Thalamus Induced By Retrieval of Morphine Withdrawal Memory

2020 ◽  
Author(s):  
Lanfang Yu ◽  
Chenshan Chu ◽  
Chao Lei ◽  
Xinli Guo ◽  
Huan Sheng ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Morphine Withdrawal ◽  
Projection Neurons ◽  
Prelimbic Cortex ◽  
Paraventricular Nucleus Of Thalamus

scholarly journals Activity in projection neurons from prelimbic cortex to the PVT is necessary for retrieval of morphine withdrawal memory

Cell Reports ◽  
2021 ◽  
Vol 35 (1) ◽  
pp. 108958
Author(s):  
Lanfang Yu ◽  
Chenshan Chu ◽  
Yu Yuan ◽  
Xinli Guo ◽  
Chao Lei ◽  
...  
Keyword(s):  
Morphine Withdrawal ◽  
Projection Neurons ◽  
Prelimbic Cortex

Effects of rolipram and diazepam on the adaptive changes induced by morphine withdrawal in the hypothalamic paraventricular nucleus

2009 ◽  
Vol 620 (1-3) ◽  
pp. 1-8 ◽  
Author(s):  
Cristina Núñez ◽  
Ana González-Cuello ◽  
Lorenzo Sánchez ◽  
M. Luisa Vargas ◽  
M. Victoria Milanés ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Morphine Withdrawal ◽  
Hypothalamic Paraventricular Nucleus ◽  
Adaptive Changes

Fine structural organization of the ependymal region of the paraventricular nucleus of the rat thalamus and its relation with projection neurons

1992 ◽  
Vol 21 (2) ◽  
pp. 105-119 ◽  
Author(s):  
G. Balercia ◽  
M. Bentivoglio ◽  
L. Kruger
Keyword(s):  
Paraventricular Nucleus ◽  
Structural Organization ◽  
Projection Neurons

scholarly journals Regulation of Serine (Ser)-31 and Ser40 Tyrosine Hydroxylase Phosphorylation during Morphine Withdrawal in the Hypothalamic Paraventricular Nucleus and Nucleus Tractus Solitarius-A2 Cell Group: Role of ERK1/2

Endocrinology ◽  
2007 ◽  
Vol 148 (12) ◽  
pp. 5780-5793 ◽  
Author(s):  
Cristina Núñez ◽  
M. Luisa Laorden ◽  
M. Victoria Milanés
Keyword(s):  
Tyrosine Hydroxylase ◽  
Paraventricular Nucleus ◽  
Nucleus Tractus Solitarius ◽  
Morphine Withdrawal ◽  
Hypothalamic Paraventricular Nucleus ◽  
Cell Group ◽  
Erk Activation ◽  
Catecholamine Biosynthesis ◽  
Hpa Axis Activity

Our previous studies have shown that naloxone-induced morphine withdrawal increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity, which is dependent on a hyperactivity of noradrenergic pathways [nucleus tractus solitarius (NTS) A2] innervating the hypothalamic paraventricular nucleus (PVN). Short-term regulation of catecholamine biosynthesis occurs through phosphorylation of tyrosine hydroxylase (TH), which enhances enzymatic activity. In the present study, the effect of morphine withdrawal on site-specific TH phosphorylation in the PVN and NTS-A2 was determined by quantitative blot immunolabeling and immunohistochemistry using phosphorylation state-specific antibodies. We show that naloxone-induced morphine withdrawal phosphorylates TH at Serine (Ser)-31 but not Ser40 in PVN and NTS-A2, which is associated with both an increase in total TH immunoreactivity in NTS-A2 and an enhanced TH activity in the PVN. In addition, we demonstrated that TH neurons phosphorylated at Ser31 coexpress c-Fos in NTS-A2. We then tested whether pharmacological inhibition of ERK activation by ERK kinase contributes to morphine withdrawal-induced phosphorylation of TH at Ser31. We show that the ability of morphine withdrawal to stimulate phosphorylation at this seryl residue is reduced by SL327, an inhibitor of ERK1/2 activation. These results suggest that morphine withdrawal increases noradrenaline turnover in the PVN, at least in part, via ERK1/2-dependent phosphorylation of TH at Ser31.

Effect of naloxone-precipitated morphine withdrawal on CRH and vasopressin mRNA expression in the rat hypothalamic paraventricular nucleus

2002 ◽  
Vol 334 (1) ◽  
pp. 58-62 ◽  
Author(s):  
M.V. Milanés ◽  
M.L. Laorden ◽  
E. Angel ◽  
P. Tankosic ◽  
A. Burlet
Keyword(s):  
Mrna Expression ◽  
Paraventricular Nucleus ◽  
Morphine Withdrawal ◽  
Hypothalamic Paraventricular Nucleus

scholarly journals Morphine withdrawal-induced c-fos expression in the hypothalamic paraventricular nucleus is dependent on the activation of catecholaminergic neurones

2002 ◽  
Vol 83 (1) ◽  
pp. 132-140 ◽  
Author(s):  
M. Luisa Laorden ◽  
Cristina Núñez ◽  
Pilar Almela ◽  
M. Victoria Milanés
Keyword(s):  
Paraventricular Nucleus ◽  
Morphine Withdrawal ◽  
Hypothalamic Paraventricular Nucleus ◽  
Fos Expression
Sign in / Sign up

Export Citation Format

Share Document