scholarly journals Depression of Non-Neuronal Cholinergic System May Play a Role in Co-Occurrence of Subjective Daytime Sleepiness and Hypertension in Patients with Obstructive Sleep Apnea Syndrome

2021 ◽  
Vol Volume 13 ◽  
pp. 2153-2163
Author(s):  
Zili Meng ◽  
Bing Sun ◽  
Wei Chen ◽  
Xilong Zhang ◽  
Mao Huang ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Daytime Sleepiness ◽  
Cholinergic System ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Comparison between Epworth Sleepiness Scale and Polysomnographic Parameters in Patients with Obstructive Sleep Apnea Syndrome

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Epworth Sleepiness Scale ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
The Relationship

Introduction: Obstructive sleep apnea syndrome (OSAS) is the most common sleep-related respiratory disorder. With the purpose of assisting in the screening or evaluation of OSAS patients, some scales and questionnaires were proposed. Objective: To evaluate and critically compare the relationship of excessive daytime sleepiness with the presence or absence of OSAS, in addition to other polysomnographic data. Material and method: Systematic review of the literature. Results: Six studies were included, with a total of 4258 patients; four studies demonstrate association between the Epworth sleepiness scale and the hypopnea apnea index (AIH); of those, two studies showed significant differences between ESS score and OSAS severity. Five studies (4233 patients) demonstrated lower minimum oxygen saturation in the group with excessive daytime sleepiness. There was an increase in sleep efficiency in in patients with excessive daytime sleepiness, as per the results of 3 studies (3002 patients). Discussion: The relationship between the presence of excessive daytime sleepiness and OSAS is still questioned, and its pathophysiological mechanism uncertain. Excessive daytime sleepiness secondary to OSAS seems to be an independent event, related to nocturnal hypoxemia and sleep fragmentation. Conclusion: The confidence intervals obtained from these studies do not provide clinical safety to use the Epworth sleepiness scale for screening or stratifying the risk of patients suspected of having sleep apnea.

scholarly journals The effect of adherence with long-term PAP therapy on the psycho-emotional state of patients with obstructive sleep apnea syndrome

2020 ◽  
Vol 17 (2) ◽  
pp. 56-60
Author(s):  
E. M. Elfimova ◽  
O. O. Mikhailova ◽  
N. T. Khachatryan ◽  
I V Starostin ◽  
A. Yu. Litvin ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Quality ◽  
Obstructive Sleep Apnea Syndrome ◽  
Daytime Sleepiness ◽  
Sleep Apnea Syndrome ◽  
Good Adherence ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Aim. To assess the impact of adherence and effectiveness of long-term positive airway pressure therapy (PAP-therapy) on the clinical and psychological characteristics of patients with obstructive sleep apnea syndrome. Materials and methods. The study included 80 patients who were examined in the sleep apnea laboratory of the Myasnikov Institute of Clinical Cardiology of the National Medical Research Center for Cardiology and who have been on PAP-therapy for more than 12 months. The average age of the patients was 65.0 years [59.0; 71.0], body mass index 35.0 kg/m2 [31.0; 38.0], sleep apnea-hypopnea index (AHI) 39.5/h [31.0; 62.6]. The average duration of PAP therapy was 3.5 years [2.0; 6.0], while the minimum use was 1 year, the maximum 15 years. In the sample of patients who came in person, the percentage of days using PAP-therapy was 87.5% [62.0; 98.0] and the average usage time 6.3 hours [5.2; 7.3]. Results. On long-term PAP-therapy a persistent decrease in AHI was seen on average from 39.5/h [31.0; 62.6] to 2.7/h [1.2; 6.2], p=0,000. The criteria for good adherence to PAP-therapy (use 4 hours/night, more than 70% of nights) were met by the percentage of days of use by 67.5% of patients, the average time of use by 87.5% of patients. Both criteria for good adherence to PAP-therapy was met by 64.8% of patients. With long-term PAP-therapy, 71.7% of patients met the criteria of effectiveness (AHI5/h), AHI remained 5/h in 22.9% of patients and the average residual AHI was 10/h in 5.4% of patients. Correlation analysis showed associations between the PAP-therapy usage parameters and the severity of obstructive sleep apnea syndrome, and sleep quality: percentage of days of use and AHI (r=0.374, p=0.001), average time of use and PSQI (r=-0.438, p=0.000). Patients with a lower adherence to PAP-therapy (63.0% of days [22.0; 96.0] and 3.6 hours [2.4; 4.5] of use) did not differ in daytime sleepiness (ESS 5.0 points [2.0; 9.0] and 5.0 points [3.0; 8.0 ], p=0.891), but had a significantly lower quality of sleep (PSQI): 18.0 points [14.0; 20.0] versus 10.0 points [7.0; 18.0], p=0.004 compared with patients with high adherence to PAP-therapy (98.0% of the days [92.0; 99.0] and 7.9 hours [7.5; 8.2] of use). Conclusions. Patients with the higher adherence to PAP-therapy had significantly better sleep quality. But even the use of PAP-therapy for less than 4 hours is associated with a decrease in daytime sleepiness severity.

Polysomnographic characteristics of daytime sleepiness in obstructive sleep apnea syndrome

2011 ◽  
Vol 16 (2) ◽  
pp. 375-381 ◽  
Author(s):  
Yuanfeng Sun ◽  
Yuping Ning ◽  
Lili Huang ◽  
Fei Lei ◽  
Zhe Li ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Daytime Sleepiness ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome
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