scholarly journals Efficacy and safety of a switch to latanoprost 0.005% + timolol maleate 0.5% fixed combination eyedrops from latanoprost 0.005% monotherapy

2012 ◽  
pp. 771 ◽  
Author(s):  
Kenji Inoue ◽  
Mieko Masumoto ◽  
Risako Higa ◽  
Masato Wakakura ◽  
Hiromi Kohmoto ◽  
...  
Keyword(s):  
Fixed Combination ◽  
Efficacy And Safety ◽  
Timolol Maleate

Comparison of Daytime Efficacy and Safety of Dorzolamide/Timolol Maleate Fixed Combination versus Latanoprost

2008 ◽  
Vol 18 (4) ◽  
pp. 556-562 ◽  
Author(s):  
J. Mulaney ◽  
S. Sonty ◽  
A. Ahmad ◽  
J.A. Stewart ◽  
W.C. Stewart
Keyword(s):  
Fixed Combination ◽  
Efficacy And Safety ◽  
Timolol Maleate

scholarly journals Efficacy and safety of timolol maleate/latanoprost fixed combination versus timolol maleate and brimonidine given twice daily

2003 ◽  
Vol 81 (3) ◽  
pp. 242-246 ◽  
Author(s):  
William C. Stewart ◽  
Jeanette A. Stewart ◽  
Douglas Day ◽  
Elizabeth D. Sharpe
Keyword(s):  
Fixed Combination ◽  
Efficacy And Safety ◽  
Timolol Maleate

scholarly journals Efficacy and safety of latanoprost versus pilocarpine/timolol maleate fixed combination in patients with primary open-angle glaucoma or ocular hypertension

2008 ◽  
Vol 86 (8) ◽  
pp. 860-865 ◽  
Author(s):  
Józef Kałużny ◽  
Roman Sobecki ◽  
Krystyna Czechowicz-Janicka ◽  
Dariusz Kecik ◽  
Bartłomiej J. Kałużny ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Fixed Combination ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Efficacy And Safety ◽  
Timolol Maleate

Efficacy and safety of fixed-combination brimonidine tartrate/timolol maleate in primary open-angle glaucoma, including normal-tension glaucoma

2021 ◽  
Vol 65 (2) ◽  
pp. 295-305
Author(s):  
Sang Woo Park ◽  
Joon Mo Kim ◽  
Ji Woong Lee ◽  
Joy Maglambayan ◽  
Susan Simonyi ◽  
...  
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Fixed Combination ◽  
Open Angle Glaucoma ◽  
Normal Tension Glaucoma ◽  
Open Angle ◽  
Efficacy And Safety ◽  
Timolol Maleate ◽  
Brimonidine Tartrate

scholarly journals Efficacy and safety of switching to latanoprost 0.005%–timolol maleate 0.5% fixed-combination eyedrops from an unfixed combination for 36 months

2014 ◽  
pp. 1275
Author(s):  
Kenji Inoue ◽  
Minako Shiokawa ◽  
Goji Tomita ◽  
Takayuki Fujimoto
Keyword(s):  
Fixed Combination ◽  
Efficacy And Safety ◽  
Timolol Maleate

scholarly journals Efficacy and safety of the latanoprost/timolol maleate fixed combination vs concomitant brimonidine and latanoprost therapy

Eye ◽  
2004 ◽  
Vol 18 (10) ◽  
pp. 990-995 ◽  
Author(s):  
W C Stewart ◽  
J A Stewart ◽  
D G Day ◽  
E D Sharpe ◽  
J N Jenkins
Keyword(s):  
Fixed Combination ◽  
Efficacy And Safety ◽  
Timolol Maleate

scholarly journals The Efficacy and Safety of Preservative-containing and Preservative-free Brimonidine-Timolol Fixed Combination in Normal Tension Glaucoma

2021 ◽  
Vol 62 (10) ◽  
pp. 1407-1414
Author(s):  
Bo Kyung Kim ◽  
Si Nae Kim ◽  
Joon Mo Kim
Keyword(s):  
Intraocular Pressure ◽  
Adverse Effects ◽  
Fixed Combination ◽  
Normal Tension Glaucoma ◽  
Eye Drops ◽  
Efficacy And Safety ◽  
Timolol Maleate ◽  
Combination Drug ◽  
Brimonidine Tartrate ◽  
Preservative Free

Purpose: To analyze the efficacy and safety of preservative-containing and preservative-free 0.2% brimonidine tartrate and 0.5% timolol maleate fixed combination drug in normal tension glaucoma.Methods: Fifty-one patients (84 eyes) who were diagnosed with normal tension glaucoma and with preservative-containing or preservative-free brimonidine-timolol fixed combinations alone were analyzed retrospectively from January 2017 to February 2020. Intraocular pressure (IOP) was measured four times a day (9 a.m., 11 a.m., 2 p.m., and 4 p.m.) before and at 6 months after applying eye drops. We analyzed and compared the effect of lowering IOP and the occurrence of intra or extra-ocular adverse effects.Results: A significant mean IOP reduction was shown in both groups: -1.95 ± 2.50 mmHg (-12.26 ± 15.87%) in the preservative-containing group and -1.60 ± 2.06 mmHg (-10.54 ± 13.94%) in the preservative-free group at 6 months after eyedrop instillation. The IOP was lowest in both groups at 11 a.m. There were no significant differences between the two groups in lowering IOP. Serious adverse effects causing discontinuation of the eye drops were not observed.Conclusions: Both preservative-containing and preservative-free brimonidine-timolol fixed combinations are effective in lowering IOP in normal tension glaucoma patients and are considered to be effective as eye drops without serious adverse effects.

scholarly journals Safety and Efficacy of Fixed Combination Travoprost-Timolol in the Lowering of Intraocular Pressure

2010 ◽  
Vol 2 ◽  
pp. CMT.S2030
Author(s):  
Robert J. Noecker ◽  
Michael J. Pokabla
Keyword(s):  
Intraocular Pressure ◽  
Fixed Combination ◽  
Patient Adherence ◽  
Open Angle Glaucoma ◽  
Efficacy And Safety ◽  
Timolol Maleate ◽  
Potential Cost ◽  
Once Daily ◽  
Safety And Efficacy ◽  
Online Resource

The fixed combination eye drop Duotrav is a combination of travoprost 0.004% and timolol maleate 0.5%. Both travoprost and timolol have been used separately for the treatment of glaucoma by lowering intraocular pressure. Multiple studies have demonstrated the efficacy and safety of the fixed combination travoprost/timolol for the treatment of open-angle glaucoma and ocular hypertension. The once daily dosing of this combination offers multiple potential advantages such as patient adherence, potential cost advantages, and reduction in exposure to preservatives. This article discusses the benefits of fixed combination medications and summarizes past and recent studies listed on the online resource PubMed of the fixed combination travoprost/timolol with comparison to both monotherapy and other similar fixed combination ocular hypotensive preparations.

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