scholarly journals Mechanisms controlling vacuolar H+-adenosine triphosphatase activity: targets for the development of new therapeutic agents for the management of osteoporosis

Author(s):  
L. Shannon Holliday ◽  
Huynh ◽  
Zuo ◽  
Toro



1963 ◽  
Vol 238 (2) ◽  
pp. 836-842
Author(s):  
D.D. Fanestil ◽  
A Baird Hastings ◽  
Theodore A. Mahowald


Nature ◽  
1965 ◽  
Vol 206 (4990) ◽  
pp. 1271-1272
Author(s):  
G. GIOVANNOZZI-SERMANNI ◽  
U. TOMATI


1973 ◽  
Vol 21 (5) ◽  
pp. 488-498 ◽  
Author(s):  
R. E. POELMANN ◽  
W. T. DAEMS ◽  
E. J. VAN LOHUIZEN

This cytochemical and electron microscopic study on peritoneal macrophages of the guinea pig has raised doubts concerning the validity of lead methods for the demonstration of plasma membrane-bound adenosine triphosphatase activity. The problems encountered are inherent in the use of lead ions as a capture reagent. The nonenzymatically formed precipitates reflect sites of heterogeneous nucleation specific for certain kinds of cells, e.g., resident peritoneal macrophages, eosinophilic granulocytes and, to a lesser degree, exudate monocytes. This type of precipitation is also catalyzed on the surface of nonbiologic matrices such as latex particles. Enzymatic processes may well occur, but they cannot be distinguished from nonenzymatic processes.



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