scholarly journals Studies of human mutation rates

1990 ◽  
Author(s):  
J V Neel
Keyword(s):  
Mutation Rates ◽  
Human Mutation

Comparison of point mutation rates in different species with human mutation rates

1972 ◽  
Vol 16 (1-2) ◽  
pp. 43-48 ◽  
Author(s):  
P. Propping
Keyword(s):  
Point Mutation ◽  
Mutation Rates ◽  
Human Mutation

Human mutation rates

Genome ◽  
1989 ◽  
Vol 31 (2) ◽  
pp. 1104-1104 ◽  
Author(s):  
James V. Neel
Keyword(s):  
Mutation Rates ◽  
Human Mutation

On the calculation of human mutation rates from changes in sex ratio

1969 ◽  
Vol 33 (1) ◽  
pp. 45-51 ◽  
Author(s):  
H. TRAUT
Keyword(s):  
Sex Ratio ◽  
Mutation Rates ◽  
Human Mutation

scholarly journals Rapid evolution of the human mutation spectrum

2016 ◽  
Author(s):  
Kelley Harris ◽  
Jonathan K. Pritchard
Keyword(s):  
Mutation Rate ◽  
Genetic Modifier ◽  
Rapid Evolution ◽  
Biological Information ◽  
Mutation Rates ◽  
Specific Sequence ◽  
Mutational Spectra ◽  
Damage Repair ◽  
Human Mutation ◽  
System Selection

AbstractDNA is a remarkably precise medium for copying and storing biological information. This high fidelity results from the action of hundreds of genes involved in replication, proofreading, and damage repair. Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts. Consistent with this, using SNV variation as a proxy for mutational input, we report here that mutational spectra differ substantially among species, human continental groups and even some closely-related populations. Close examination of one signal, an increased TCC→TTC mutation rate in Europeans, indicates a burst of mutations from about 15,000 to 2,000 years ago, perhaps due to the appearance, drift, and ultimate elimination of a genetic modifier of mutation rate. Our results suggest that mutation rates can evolve markedly over short evolutionary timescales and suggest the possibility of mapping mutational modifiers.

Genes & cells: Sperm's genetic blueprint compiled: Analysis uses sex cells to calculate human mutation rates

Science News ◽  
2012 ◽  
Vol 182 (4) ◽  
pp. 14-14
Author(s):  
Tina Hesman Saey
Keyword(s):  
Mutation Rates ◽  
Human Mutation ◽  
Sex Cells

scholarly journals Studies of human mutation rates. Progress report, November 1992--October 1993

1993 ◽  
Author(s):  
J.V. Neel ◽  
S.M. Hanash
Keyword(s):  
Progress Report ◽  
Mutation Rates ◽  
Human Mutation

scholarly journals Studies of human mutation rates. Progress report, November 1, 1993--October 31, 1994

1994 ◽  
Author(s):  
J.V. Neel ◽  
S.M. Hanash
Keyword(s):  
Progress Report ◽  
Mutation Rates ◽  
Human Mutation

Potential DNA methods for measuring the human heritable mutation rate

Genome ◽  
1989 ◽  
Vol 31 (2) ◽  
pp. 860-863 ◽  
Author(s):  
Mortimer L. Mendelsohn
Keyword(s):  
Mutation Rate ◽  
Human Sperm ◽  
Mutation Rates ◽  
Practical Implementation ◽  
Dna Technology ◽  
Heritable Mutation ◽  
Human Mutation ◽  
Potential Methods

Potential methods are reviewed for estimating human heritable mutation rates by comparing the DNA of parents and offspring. In the 4 years since the Alta Workshop on this subject, information has accumulated on several of the six methods detailed in that meeting. Some of the methods now appear to be infeasible, and all continue to be too inefficient for practical implementation. Newer DNA approaches are discussed, including several that could become practical enough for implementation. Finally, DNA-oriented methods using human sperm are considered as possible alternatives to the heritable approaches.Key words: human heritable mutation, human mutation rate, DNA method – DNA technology, radiation.

Estimating human mutation rates from polymorphisms

Nature ◽  
1978 ◽  
Vol 274 (5674) ◽  
pp. 845-846 ◽  
Author(s):  
J. H. Edwards
Keyword(s):  
Mutation Rates ◽  
Human Mutation

scholarly journals Studies of human mutation rates

1991 ◽  
Author(s):  
J.V. Neel
Keyword(s):  
Mutation Rates ◽  
Human Mutation
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