Synthesis and Structure of New N-Bromobenzyl Bis-quinolizidine Derivatives

2012 ◽  
Vol 9 (7) ◽  
pp. 474-477
Author(s):  
Beata Jasiewicz ◽  
Karolina Malczewska-Jaskola ◽  
Katarzyna Polom
Keyword(s):  
Quinolizidine Derivatives

Notes- Benzo[b]quinolizidine Derivatives

1960 ◽  
Vol 25 (2) ◽  
pp. 294-295 ◽  
Author(s):  
C Bradsher ◽  
Nancy Yarrington
Keyword(s):  
Quinolizidine Derivatives

scholarly journals ETM-ANN Approach Application for Thiobenzamide and Quinolizidine Derivatives

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
M. Saracoglu ◽  
F. Kandemirli ◽  
V. Kovalishyn ◽  
T. Arslan ◽  
E. E. Ebenso
Keyword(s):  
Chemical Potential ◽  
Electrophilicity Index ◽  
Activity Data ◽  
Fusion Inhibitors ◽  
Influenza Activity ◽  
Qsar Models ◽  
Quinolizidine Derivatives ◽  
Artificial Neural Network Ann ◽  
The One ◽  
External Test

The structure anti-influenza activity relationships of thiobenzamide and quinolizidine derivatives, being influenza fusion inhibitors, have been investigated using the electronic-topological method (ETM) and artificial neural network (ANN) method. Molecular fragments specific for active compounds and breaks of activity were calculated for influenza fusion inhibitors by applying the ETM. QSAR descriptors such as molecular weight,EHOMO,ELUMO,ΔE, chemical potential, softness, electrophilicity index, dipole moment, and so forth were calculated, and it was found to give good statistical qualities (classified correctly 92%, or 48 compounds from 52 in training set, and 69% or 9 compounds from 13 in the external test set). By using multiple linear regression, several QSAR models were performed with the help of calculated descriptors and the compounds activity data. Among the obtained QSAR models, statistically the most significant one is the one of skeleton 1 withR2=0.999.

Rearrangements and Cyclizations of 2-Chloropropenyl-Appended Indolo[2,3-a]quinolizidine Derivatives

1999 ◽  
Vol 1999 (12) ◽  
pp. 3429-3432 ◽  
Author(s):  
Samia Aït-Mohand ◽  
Eric Noé ◽  
Jacques Hénin ◽  
Jean-Yves Laronze
Keyword(s):  
Quinolizidine Derivatives
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