scholarly journals Preclinical Formulation in Early Drug Research

2012 ◽  
pp. 68-85
Keyword(s):  
Drug Research ◽  
Early Drug

Pharmacokinetics in Early Drug Research

1997 ◽  
Vol 25 (1) ◽  
pp. 17-31
Author(s):  
David E. Leahy ◽  
Ruth Duncan ◽  
Hans J. Ahr ◽  
Martin K. Bayliss ◽  
A. (Bert) G. de Boer ◽  
...  
Keyword(s):  
Drug Research ◽  
Early Drug

scholarly journals Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events

2012 ◽  
Vol 33 (2) ◽  
pp. 72-84 ◽  
Author(s):  
Christopher L. Shaffer ◽  
Renato J. Scialis ◽  
Haojing Rong ◽  
R. Scott Obach
Keyword(s):  
Adverse Events ◽  
Drug Research ◽  
Pharmacokinetic Variability ◽  
Early Drug

scholarly journals Predicting drug metabolism: Concepts and challenges

2004 ◽  
Vol 76 (5) ◽  
pp. 907-914 ◽  
Author(s):  
B. Testa ◽  
A.-L. Balmat ◽  
Anthony Long
Keyword(s):  
Drug Metabolism ◽  
In Silico ◽  
Drug Research ◽  
Metabolic Data ◽  
Global Systems ◽  
Early Drug ◽  
In Silico Methods

The paper begins with a discussion of the needs and goals of metabolic predictions in early drug research. Major difficulties toward this objective are examined, mainly the various substrate and product selectivities characteristic of drug metabolism. In a second part, we classify and summarize the major in silico methods used to predict drug metabolism. A discrimination is thus made between “local ”and “global ”systems. In the last part of the paper, the program METEOR is presented and evaluated using the published metabolic data of 10 substrates.

Drug research today

2001 ◽  
Vol 18 (Suppl. 23) ◽  
pp. 21-25 ◽  
Author(s):  
E. D. Sprengers
Keyword(s):  
Drug Research
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