Oral Administration of Solanum Macrocarpon Leaf Extracts Reduced Blood Pressure and Heart Rate in Spontaneously Hypertensive Rats

The aim of this work was to determine the ability of polyphenol-enriched aqueous vegetable leaf extracts to ameliorate blood pressure and heart rate dysfunctions in spontaneously hypertensive rats (SHRs). Solanum macrocarpon (SM), a common edible vegetable leaf in West Africa was cultivated using varying levels (0-80 kg/ha) of urea that was applied at planting (T1) or 2 weeks after planting (T2). In vitro analysis showed that total polyphenolic compounds varied from 489.87 ± 5.66 to 513.56 ± 1.42 mg gallic acid equivalent/g dry wt of extract. Rutin, caffeic acid and myricetin were the major polyphenols quantified in the extracts. All the extracts inhibited in vitro activities of renin and angiotensin converting enzyme to varying extents. Two extracts (SM40T1 and SM80T2) were orally administered to SHRs at 100 or 500 mg/kg body wt. Results showed that systolic blood pressure was reduced to a similar level by SM40T1 (10.8 mmHg) and SM80T2 (10.5 mmHg) for the 100 mg/kg body wt dose; the 500 mg/kg body wt dose produced similar values. Diastolic blood pressure and heart rate were also depressed by the two extracts with similar effects observed for both doses. We conclude that the leaf extracts could serve as potential ingredients to formulate antihypertensive functional foods and nutraceuticals.

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Effects of long-term oral administration of centrally acting antihypertensive drugs on blood pressure and heart rate of spontaneously hypertensive rats

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)53566-1 ◽

1980 ◽

Vol 30 ◽

pp. 175

Author(s):

Yuichi Koike ◽

Hiroko Togashi ◽

Itaru Yomaida ◽

Keiichi Shimamura ◽

Masahisa Saikawa ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Oral Administration ◽

Spontaneously Hypertensive Rats ◽

Antihypertensive Drugs ◽

Hypertensive Rats ◽

Spontaneously Hypertensive

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Attenuation of the increase in blood pressure and vascular reactivity by chronic oral administration of soft-shelled turtle powder in spontaneously hypertensive rats

Phytotherapy Research ◽

10.1002/ptr.2650040205 ◽

1990 ◽

Vol 4 (2) ◽

pp. 57-61 ◽

Cited By ~ 4

Author(s):

Hong Feng ◽

Norio Matsuki ◽

Hiroshi Saito

Keyword(s):

Blood Pressure ◽

Oral Administration ◽

Spontaneously Hypertensive Rats ◽

Vascular Reactivity ◽

Hypertensive Rats ◽

Spontaneously Hypertensive

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Regression of myocardial hypertrophy and influence of adrenergic system

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1983.244.1.h97 ◽

1983 ◽

Vol 244 (1) ◽

pp. H97-H101 ◽

Cited By ~ 4

Author(s):

S. Sen ◽

R. C. Tarazi

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Regression Analysis ◽

Arterial Pressure ◽

Spontaneously Hypertensive Rats ◽

Myocardial Hypertrophy ◽

Cardiac Response ◽

Adrenergic System ◽

Hypertensive Rats ◽

Spontaneously Hypertensive

Studies of regression of myocardial hypertrophy in spontaneously hypertensive rats (SHR) suggest that the adrenergic system may play an important role in the reversal of hypertrophy. The effect of propranolol on reversal of hypertrophy, however, is still controversial. This study describes the effect of propranolol, given alone or in combination with hydralazine in different ratios for 4 wk, on blood pressure (BP), ventricular weight, and myocardial catecholamine (MC) concentrations. The data show that a certain ratio of propranolol to hydralazine (750:30) leads to moderate BP control (196-156 mmHg) without increased MC (634 vs. 552 ng/g) and moderately reduced hypertrophy. Reduction of BP alone with increased MC (hydralazine alone) or reduction of MC without BP control (propranolol alone) failed to reduce hypertrophy. A significant correlation between both ventricular weight and heart rate with MC (r = 0.6) was obtained by multiple regression analysis. This study suggests that adrenergic factors seem to play an important role in modulating structural cardiac response to variations in arterial pressure.

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