Anti-platelet antibodies in sera from patients with systemic lupus erythematosus by immunoblot analysis.

SummaryImmunoblot analysis of sperm protein from several species revealed the presence of polypeptides recognised by anti-Sm sera obtained from patients with systemic lupus erythematosus. Immunoreactive polypeptides in human, bull, mouse and rat sperm were identified as protein B', B and D as compared with the Sm polypeptides of HeLa cells. In the sperm of rooster, the teleost fish Cyprinus carpio and the mussel Choromytilus chorus, the immunoreactive polypeptide profile was more complex. To ascertain the sperm origin of the Sm antigens, immunolocalisation with anti-Sm serum was carried out. The results demonstrated that in all the specied studied staining was confinde to the sperm nucleus, confirming that some polypeptides of the small nuclear ribonnucleoprotein complex are present in the gamete.

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Anti‐platelet antibodies in patients with systemic lupus erythematosus and the primary antiphospholipid antibody syndrome: their relationship with the observed thrombocytopenia

British Journal of Haematology ◽

10.1046/j.1365-2141.1997.2243038.x ◽

1997 ◽

Vol 98 (2) ◽

pp. 336-341 ◽

Cited By ~ 74

Author(s):

Laurent Macchi ◽

Patrick Rispal ◽

Gisèle Clofent‐Sanchez ◽

Jean‐Luc Pellegrin ◽

Paquita Nurden ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Antiphospholipid Antibody ◽

Antiphospholipid Antibody Syndrome ◽

Systemic Lupus ◽

Platelet Antibodies

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Thrombotic thrombocytopenic purpura in two patients with systemic lupus erythematosus: Clinical significance of anti-platelet antibodies

Clinical Immunology and Immunopathology ◽

10.1016/0090-1229(90)90028-o ◽

1990 ◽

Vol 57 (1) ◽

pp. 125-136 ◽

Cited By ~ 14

Author(s):

Yoshihiro Itoh ◽

Hiromi Sekine ◽

Osamu Hosono ◽

Tsutomu Takeuchi ◽

Jun Koide ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Thrombotic Thrombocytopenic Purpura ◽

Clinical Significance ◽

Lupus Erythematosus ◽

Systemic Lupus ◽

Thrombocytopenic Purpura ◽

Platelet Antibodies

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Circulating Anticoagulant against Factor XII and Platelet Antibodies in Systemic Lupus Erythematosus

Acta Haematologica ◽

10.1159/000207872 ◽

1977 ◽

Vol 57 (3) ◽

pp. 135-142 ◽

Cited By ~ 6

Author(s):

G.M. Gandolfo ◽

A. Afeltra ◽

A. Amoroso ◽

F. Biancolella ◽

G.M. Ferri

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Factor Xii ◽

Systemic Lupus ◽

Platelet Antibodies

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Detection of Immunoprecipitated Systemic Lupus Erythematosus Antigens by Immunoblot Analysis

Journal of Immunoassay ◽

10.1080/01971529008055048 ◽

1990 ◽

Vol 11 (4) ◽

pp. 519-543

Author(s):

Cynthia B. Rothschild ◽

Bill A. Kilpatrick

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Immunoblot Analysis ◽

Systemic Lupus

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Organized Intraglomerular Deposits in NZB Mouse Disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066772 ◽

1971 ◽

Vol 29 ◽

pp. 544-545

Author(s):

Francis R. Comerford ◽

Alan S. Cohen

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Antinuclear Antibodies ◽

Human Systemic Lupus Erythematosus ◽

Systemic Lupus ◽

Glomerular Lesion ◽

Ultrastructural Studies ◽

Dense Deposits ◽

Experimental Nephritis ◽

Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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