The Use of Mixture Models for the Analysis of Survival Data with Long-Term Survivors

Biometrics ◽  
1982 ◽  
Vol 38 (4) ◽  
pp. 1041 ◽  
Author(s):  
V. T. Farewell
1994 ◽  
Vol 49 (2) ◽  
pp. 218-241 ◽  
Author(s):  
M.E. Ghitany ◽  
R.A. Maller ◽  
S. Zhou

2021 ◽  
Vol 39 (2) ◽  
pp. 293-310
Author(s):  
Talita Evelin Nabarrete Tristão de MORAES ◽  
Isolde PREVIDELLI ◽  
Giovani Loiola da SILVA

Breast cancer is one of the most common diseases among women worldwide with about 25% of new cases each year. In Brazil, 59,700 new cases of breast cancer were expected in 2019, according to the Brazilian National Cancer Institute (INCA). Survival analysis has been an useful tool for the identifying the risk and prognostic factors for cancer patients. This work aims to characterize the prognostic value of demographic, clinical and pathological variables in relation to the survival time of 2,092 patients diagnosed with breast cancer in Parana State, Brazil, from 2004 to 2016. In this sense, we propose a Bayesian analysis of survival data with long-term survivors by using Weibull regression models through integrated nested Laplace approximations (INLA). The results point to a proportion of long-term survivors around 57:6% in the population under study. In regard to potential risk factors, we namely concluded that 40-50 year age group has superior survival than younger and older age groups, white women have higher breast cancer risk than other races, and marital status decreases that risk. Caution on the general use of these results is nevertheless advised, since we have analyzed population-based breast cancer data without proper monitoring by a healthprofessional.


Author(s):  
Umar Usman ◽  
Shamsuddeen Suleiman ◽  
Bello Magaji Arkilla ◽  
Yakubu Aliyu

In this paper, a new long term survival model called Nadarajah-Haghighi model for survival data with long term survivors was proposed. The model is used in fitting data where the population of interest is a mixture of individuals that are susceptible to the event of interest and individuals that are not susceptible to the event of interest. The statistical properties of the proposed model including quantile function, moments, mean and variance were provided. Maximum likelihood estimation procedure was used to estimate the parameters of the model assuming right censoring. Furthermore, Bayesian method of estimation was also employed in estimating the parameters of the model assuming right censoring. Simulations study was performed in order to ascertain the performances of the MLE estimators. Random samples of different sample sizes were generated from the model with some arbitrary values for the parameters for 5%, 1:3% and 1:5% cure fraction values. Bias, standard error and mean square error were used as discrimination criteria. Additionally, we compared the performance of the proposed model with some competing models. The results of the applications indicates that the proposed model is more efficient than the models compared with. Finally, we fitted some models considering type of treatment as a covariate. It was observed that the covariate  have effect on the shape parameter of the proposed model.


Biometrics ◽  
2016 ◽  
Vol 72 (4) ◽  
pp. 1348-1357 ◽  
Author(s):  
Wei‐Wen Hsu ◽  
David Todem ◽  
KyungMann Kim

2004 ◽  
Vol 23 (22) ◽  
pp. 3525-3543 ◽  
Author(s):  
Quanxi Shao ◽  
Xian Zhou

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