Since the eighteenth century, yellow fever has had a racialized history in New Orleans and elsewhere in the Americas stemming, in part, from the disease’s origins in West Africa. There was a misconception that blacks were less likely to fall victim to the disease. This article establishes the theories around contagion and susceptibility, showing that whites, especially foreigners, were thought to be at greater risk for what was called the “Strangers’ Disease.” It then analyzes three nineteenth-century novels about New Orleans wherein yellow fever plays an important role. Two of the novels are quite well known: The Grandissimes: A Story of Creole Life (1880) by George Washington Cable and Chita: A Memory of Last Island (1889) by Lafcadio Hearn. The third novel, Amitié et dévouement, ou Trois mois à la Louisiane (1845) by Camille Lebrun, although virtually forgotten, is especially important as it represents the voice of a French woman writer whose views on race differ from those of the two other authors.