scholarly journals Acral acanthosis nigricans may be a marker of internal malignancy

2021 ◽  
Vol 1 ◽  
pp. 58
Author(s):  
Arunachalam Narayanan ◽  
Sunke Vamshi Anurag
Keyword(s):  
Acanthosis Nigricans ◽  
Internal Malignancy

scholarly journals Malignant acanthosis nigricans: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiaoyan Zhang ◽  
Rongjun Liu ◽  
Yiyun Liu ◽  
Shuang Zhang ◽  
Hong Qi
Keyword(s):  
Thyroid Cancer ◽  
Case Report ◽  
Gastric Adenocarcinoma ◽  
Acanthosis Nigricans ◽  
Case Presentation ◽  
Internal Malignancy ◽  
Malignant Acanthosis Nigricans ◽  
Eye Symptoms ◽  
Thyroid Lesions ◽  
Dry Eye Symptoms

Abstract Background To report a case of malignant acanthosis nigricans with two unusual aspects, including the patient’s young age and the development of filiform papillomas on the eyelid margins. Case presentation A 30-year-old woman presented with dry eye symptoms. Examination revealed filiform papillomas on the eyelid margins, gums, lips, hands, and axillae and excessive pigmentation localized to the neck, axillae, and groin. Biopsies of stomach, pancreatic, and thyroid lesions revealed gastric adenocarcinoma, pancreatic adenocarcinoma, and thyroid cancer, respectively. Systemic investigations showed gastric adenocarcinoma with metastatic spread. The patient was ultimately diagnosed with malignant acanthosis nigricans and died 4 months later. Conclusions Acanthosis nigricans on the eyelid margins with a velvety overgrowth is highly suggestive of an internal malignancy, and full systemic investigations are warranted in these cases. In this patient, early signs were ignored, leading to the loss of a timely diagnosis and treatment.

Oral Acanthosis Nigricans as a Marker of Internal Malignancy. A Case Report

2001 ◽  
Vol 72 (9) ◽  
pp. 1271-1275 ◽  
Author(s):  
Francesco Cairo ◽  
Ida Rubino ◽  
Roberto Rotundo ◽  
Giovanpaolo Pini Prato ◽  
Giuseppe Ficarra
Keyword(s):  
Case Report ◽  
Acanthosis Nigricans ◽  
Internal Malignancy

scholarly journals Malignant Acanthosis Nigricans: An Indicator of Internal Malignancy

2019 ◽  
Vol 29 (09) ◽  
pp. 888-890
Author(s):  
Muhammad Rizwan ◽  
Nadia Iftikhar ◽  
Tariq Sarfraz ◽  
Obed Ullah
Keyword(s):  
Acanthosis Nigricans ◽  
Internal Malignancy ◽  
Malignant Acanthosis Nigricans

scholarly journals Generalised idiopathic benign acanthosis nigricans with onset during infancy: report of two patients

2017 ◽  
Vol 3 (9) ◽  
pp. 252
Author(s):  
Avani Hegde ◽  
Keerthivasan Seetharaman ◽  
Anshita Aggarwal ◽  
Devi Dayal
Keyword(s):  
Insulin Resistance ◽  
Acanthosis Nigricans ◽  
Watchful Waiting ◽  
Systemic Disease ◽  
Internal Malignancy ◽  
Spontaneous Improvement ◽  
Benign Course

<p>Generalised acanthosis nigricans (AN) is usually seen in association with insulin resistance or internal malignancy in adults. Very rarely, this may occur in children without any evidence of systemic disease and runs a benign course. Its management requires only watchful waiting. Here, we report two children with benign AN who had onset of AN during infancy and showed spontaneous improvement during follow up for a mean duration of 7.7±0.14 years.</p>

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