scholarly journals Criteria for the reliability of optical coherence tomography measurements in patients with age-related cataract

2021 ◽  
pp. 6-11
Author(s):  
A.A. Shpak ◽  
◽  
A.A. Troshina ◽  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Signal Strength ◽  
Reliable Data ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Age Related ◽  
Central Subfield Thickness

Purpose. To determine optimal criteria for reliable optical coherence tomography (OCT) measurements in patients with age-related cataract. Material and methods. We examined 83 patients (83 eyes) with agerelated cataract before and after cataract surgery. The intensity of lens opacity was assessed by the Cirrus HD-OCT signal strength and Pentacambased Scheimpflug images analysis. Clinical cataract grading was performed according to the WHO classification. Preoperative measurement was considered reliable if its' difference with postoperative measurement did not exceed 5 ?m for the peripapillary retinal nerve fiber layer thickness (pRNFL) and 8 ?m for the central subfield thickness. Results. According to the ROC analysis, only the OCT signal strength allows to distinguish reliable OCT measurements: area under the ROC-curve (AUC) of the OCT signal strength was 0.815 (95% confidence interval 0.720–0.909) for the pRNFL and 0.756 (95% CI: 0.632–0.880) for the central subfield thickness. The best signal strength thresholds for reliable data were 5.5 for pRNFL and 4.5 for the central macular thickness (considering that the signal strength is measured in integers, these values should be rounded to 6 and 5 respectively). The rest of the studied parameters had AUC less than 0.6 so they cannot be used for evaluating OCT data. Conclusion. In patients with age-related cataract, only OCT signal strength can determine reliability of the OCT measurements. The lowest signal strength for reliable data on the Cirrus HD-OCT is 6 for pRNFL and 5 for centr al subfield thickness. Key words: optical coherence tomography, cataract, retina, nerve fiber layer, lens densitometry.

Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography

2008 ◽  
Vol 14 (7) ◽  
pp. 893-905 ◽  
Author(s):  
F Costello ◽  
W Hodge ◽  
YI Pan ◽  
E Eggenberger ◽  
S Coupland ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Introduction Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography. Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis. Methods This prospective case series included 78 patients with optic neuritis, who underwent optical coherence tomography and visual testing over a mean period of 28 months. The main outcome measures included comparing inter-eye differences in retinal nerve fiber layer thickness between clinically affected and non-affected eyes over time; establishing when RNFL thinning stabilized after optic neuritis; and correlating retinal nerve fiber layer thickness and visual function. Results The earliest significant inter-eye differences manifested 2-months after optic neuritis, in the temporal retinal nerve fiber layer. Inter-eye comparisons revealed significant retinal nerve fiber layer thinning in clinically affected eyes, which persisted for greater than 24 months. Retinal nerve fiber thinning manifested within 6 months and then stabilized from 7 to 12 months after optic neuritis. Regression analyses demonstrated a threshold of nerve fiber layer thickness (75μm), which predicted visual recovery after optic neuritis. Conclusions Retinal nerve fiber layer changes may be tracked and correlated with visual function within 12 months of an optic neuritis event.

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