PERAN IMUNITAS HUMORAL PADA PENYAKIT  SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

Lupus Erythematosus ◽

Systemic Lupus ◽

Systemic Lupus Erythematosus (SLE) adalah suatu kelainan autoimun multisistem kronik yang ditandai oleh autoantibodi dan kompleks imun yang berkaitan dengan manifestasi klinis dan kerusakan jaringan yang beragam dan luas. Beberapa defek dari komponen imunologi multipel berperan penting dalam patogenesis SLE. Abnormalitas imunologi pada SLE meliputi kemampuan untuk menghasilkan autoantibodi patogenik, hilangnya regulasi sel limfosit B dan T, serta defective clearance dari autoantigen dan kompleks imun. Faktor genetik, imunologik dan hormonal serta lingkungan diduga berperan dalam patofisiologi SLE. Tulisan ini mengkaji respon imun humoral sebagai salah satu patogenesis SLE.

Circulating nucleosomes due to a defective clearance of dying cells: Consequences for systemic lupus erythematosus

Autoimmunity ◽

10.1080/08916930701356358 ◽

2007 ◽

Vol 40 (4) ◽

pp. 311-314 ◽

Cited By ~ 2

Author(s):

Annika I. M. Erbacher ◽

Viktoria M. Rönnefarth ◽

Patrice Decker

Keyword(s):

Lupus Erythematosus ◽

Systemic Lupus ◽

Dying Cells ◽

Defective clearance of nucleosomes and systemic lupus erythematosus

Trends in Immunology ◽

10.1016/s1471-4906(01)02084-1 ◽

2001 ◽

Vol 22 (12) ◽

pp. 662-663 ◽

Cited By ~ 8

Author(s):

Yoichi Maekawa ◽

Koji Yasutomo

Keyword(s):

Lupus Erythematosus ◽

Systemic Lupus ◽

Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus

Rheumatology ◽

10.1093/rheumatology/keg081 ◽

2003 ◽

Vol 42 (2) ◽

pp. 214-222 ◽

Cited By ~ 22

Author(s):

K. Yasutomo

Keyword(s):

Lupus Erythematosus ◽

Lymphocyte Activation ◽

Systemic Lupus ◽

Organized Intraglomerular Deposits in NZB Mouse Disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066772 ◽

1971 ◽

Vol 29 ◽

pp. 544-545

Author(s):

Francis R. Comerford ◽

Alan S. Cohen

Keyword(s):

Lupus Erythematosus ◽

Antinuclear Antibodies ◽

Human Systemic Lupus Erythematosus ◽

Systemic Lupus ◽

Glomerular Lesion ◽

Ultrastructural Studies ◽

Dense Deposits ◽

Experimental Nephritis ◽

Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.