Correlation between Chondroitin Sulfate Iron Colloid-Enhanced MR Imaging and the Histological Grade of Hepatocellular Carcinoma

1995 ◽  
Vol 36 (1) ◽  
pp. 102-105 ◽  
Author(s):  
Y. Suto ◽  
F. Kodama ◽  
M. Kamba ◽  
Y. Ohta
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Chondroitin Sulfate ◽  
Histological Grade

Correlation between Chondroitin Sulfate Iron Colloid-Enhanced MR Imaging and the Histological Grade of Hepatocellular Carcinoma

1995 ◽  
Vol 36 (1) ◽  
pp. 102-105 ◽  
Author(s):  
Y. Suto ◽  
F. Kodama ◽  
M. Kamba ◽  
Y. Ohta
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Chondroitin Sulfate ◽  
Contrast Enhancement ◽  
Histological Examination ◽  
Histological Grade ◽  
Poorly Differentiated ◽  
Noise Ratio ◽  
Well Differentiated ◽  
T2 Weighted Images

The association between contrast enhancement by chondroitin sulfate iron colloid (CSIC) and the histological grade of hepatocellular carcinoma (HCC) was evaluated in 24 patients diagnosed by histological examination of surgical specimens (26 nodules: 11 well-differentiated and 15 poorly—moderately-differentiated nodules). In the well-differentiated HCC nodules, the tumor—liver contrast to noise ratio (CNR) was not significantly increased after i.v. CSIC injection on both T1-weighted and T2-weighted images. In the moderately-poorly-differentiated HCC, CNR was significantly increased after CSIC administration on both T1-weighted and T2-weighted images (p<0.01). MR imaging using CSIC may be useful for diagnosing the degree of HCC differentiation.

Chondroitin Sulfate Iron Colloid-Enhanced MR Imaging in Patients with Hepatocellular Carcinoma

1994 ◽  
Vol 35 (6) ◽  
pp. 570-575 ◽  
Author(s):  
M. Kamba ◽  
Y. Suto ◽  
T. Kato
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Chondroitin Sulfate ◽  
Spin Echo ◽  
Proton Density ◽  
Mr Images ◽  
Portal Flow ◽  
Ct During Arterial Portography ◽  
Before And After

Chondroitin sulfate iron colloid (CSIC) was used as an MR contrast agent for the detection of hepatocellular carcinoma (HCC). The findings of 25 surgically confirmed HCCs in 19 patients were retrospectively analyzed. T1-, T2- and proton density-weighted spin echo MR images were obtained before and after i.v. injection of 23.6 μM Fe/kg of CSIC. Unenhanced and CSIC-enhanced MR images and images obtained by CT during arterial portography (CT-AP) were correlated with surgical pathology findings. The sensitivities of CSIC-enhanced and unenhanced MR imaging, and CT-AP were 92%, 80%, and 88%, respectively. No significant differences were noted. Portal flow abnormalities demonstrated by CT-AP did not affect the detection of HCC by CSIC-enhanced MR imaging. CSIC-enhancement at MR imaging was a disadvantage in the detection of lesions less than 1 cm in diameter. CSIC-enhanced MR imaging is a supplemental method for the detection of HCC.

MR Imaging of Hepatocellular Carcinoma

1995 ◽  
Vol 36 (2) ◽  
pp. 163-167 ◽  
Author(s):  
H. Honda ◽  
H. Onitsuka ◽  
Y. Kanazawa ◽  
T. Matsumata ◽  
T. Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mr Imaging
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