Characterization of the Precipitates of Poorly Water Soluble Drugs and Determination of the Solubilities in Human Gastro-Intestinal Fluids by Microsopy

1993 ◽  
Vol 19 (10) ◽  
pp. 1103-1112 ◽  
Author(s):  
D. M. Simmons
Keyword(s):  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Intestinal Fluids ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

scholarly journals Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 745
Author(s):  
Thao T. D. Tran ◽  
Phuong H. L. Tran
Keyword(s):  
Molecular Interactions ◽  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Potent Drug

Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.

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