Differential expression of coding and non-coding RBPMS transcripts in cancers of the breast.

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding RBPMS antisense RNA 1, RBPMS-AS1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. RBPMS-AS1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. In a separate dataset, a coding RNA transcribed at the RBPMS locus was differentially expressed in primary tumors of the breast. Analysis of human survival data revealed that primary tumor expression of RBPMS-AS1 was correlated with overall survival in patients with luminal A and HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. RBPMS-AS1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of phosphodiesterase 7B in cancers of the breast.

10.31219/osf.io/ymgu3 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding phosphodiesterase 7B, PDE7B, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDE7B mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDE7B in primary tumors of the breast was correlated with recurrence-free survival in patients with basal subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PDE7B may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of ATPase Na+/K+ transporting subunit alpha 2 in cancers of the breast.

10.31219/osf.io/nf6qb ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding ATPase Na+/K+ transporting subunit alpha 2, ATP1A2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ATP1A2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ATP1A2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ATP1A2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of phosphodiesterase 2A in cancers of the breast.

10.31219/osf.io/x62kb ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding phosphodiesterase 2A, PDE2A, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PDE2A mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PDE2A in primary tumors of the breast was correlated with overall survival in patients with basal subtype breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PDE2A may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of calcium and integrin binding 1 in cancers of the breast.

10.31219/osf.io/r9p8x ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding calcium and integrin binding 1, CIB1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CIB1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CIB1 in primary tumors of the breast was correlated with overall survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. CIB1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of spexin hormone in cancers of the breast.

10.31219/osf.io/jcva4 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding spexin hormone, SPX, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SPX mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SPX in primary tumors of the breast was correlated with distant metastasis-free survival in patients with basal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. SPX may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of HPSE2 in cancers of the breast.

10.31219/osf.io/astvr ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding heparanase 2 (inactive), HPSE2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. HPSE2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. HPSE2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of HPSE2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. HPSE2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of klotho beta in cancers of the breast.

10.31219/osf.io/s823v ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding klotho beta, KLB, when comparing primary tumors of the breast to the tissue of origin, the normal breast. KLB mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of KLB in primary tumors of the breast was correlated with distant metastasis-free survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. KLB may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of aspartoacylase in cancers of the breast.

10.31219/osf.io/3a6wm ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding aspartoacylase, ASPA, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ASPA mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ASPA in primary tumors of the breast was correlated with overall survival in patients with basal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ASPA may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of caveolin 2 in cancers of the breast.

10.31219/osf.io/5dgra ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding caveolin 2, CAV2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CAV2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CAV2 in primary tumors of the breast was correlated with overall survival in patients with basal subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. CAV2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of calsequestrin 2 in cancers of the breast.

10.31219/osf.io/234uk ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding calsequestrin 2, CASQ2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CASQ2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CASQ2 in primary tumors of the breast was correlated with recurrence-free survival in patients with normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. CASQ2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.