Differential expression of betaine--homocysteine S-methyltransferase 2 in cancers of the breast.

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding betaine--homocysteine S-methyltransferase 2, BHMT2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. BHMT2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of BHMT2 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. BHMT2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of tescalcin in cancers of the breast.

10.31219/osf.io/5xjak ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding tescalcin, TESC, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TESC was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TESC mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TESC in primary tumors of the breast was correlated with overall survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. TESC may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of transformer 2 alpha homolog in cancers of the breast.

10.31219/osf.io/2ngvq ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding transformer 2 alpha homolog, TRA2A, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TRA2A was also differentially expressed in the tumor cells of patients with triple negative breast cancer. TRA2A mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TRA2A in primary tumors of the breast was correlated with overall survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. TRA2A may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of CEP112 in cancers of the breast.

10.31219/osf.io/mvpz3 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding centrosomal protein 112, CEP112, also known as FAM126A, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CEP112 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CEP112 in primary tumors of the breast was correlated with post-progression survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. CEP112 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of p21 (RAC1) activated kinase 3 in cancers of the breast.

10.31219/osf.io/vtdgw ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding p21 (RAC1) activated kinase 3, PAK3, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PAK3 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. PAK3 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PAK3 in primary tumors of the breast was correlated with post-progression survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. PAK3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of CUGBP, Elav-like family member 2 in cancers of the breast.

10.31219/osf.io/c38hm ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding angiopoietin 1, ANGPT1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ANGPT1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ANGPT1 in primary tumors of the breast was correlated with overall survival in patients with luminal B and normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ANGPT1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of plexin A4 in cancers of the breast.

10.31219/osf.io/c4s7k ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding plexin A4, PLXNA4, when comparing primary tumors of the breast to the tissue of origin, the normal breast. PLXNA4 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of PLXNA4 in primary tumors of the breast was correlated with overall survival in patients with luminal B, HER2+, and normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. PLXNA4 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of EGFLAM in cancers of the breast.

10.31219/osf.io/kvgam ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding EGF like, fibronectin type III and laminin G domains, EGFLAM, when comparing primary tumors of the breast to the tissue of origin, the normal breast. EGFLAM mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of EGFLAM in primary tumors of the breast was correlated with overall survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. EGFLAM may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of myomesin 1 in cancers of the breast.

10.31219/osf.io/fgkzw ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding myomesin 1, MYOM1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. MYOM1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of MYOM1 in primary tumors of the breast was correlated with overall survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. MYOM1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of FDXACB1 in cancers of the breast.

10.31219/osf.io/w2ruy ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding ferredoxin-fold anticodon binding domain containing 1, FDXACB1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FDXACB1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FDXACB1 in primary tumors of the breast was correlated with overall survival in patients with luminal B and HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. FDXACB1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

Differential expression of tenomodulin in cancers of the breast.

10.31219/osf.io/jb627 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Differential Expression ◽

Survival Data ◽

Molecular Subtype ◽

Normal Breast ◽

Primary Tumors ◽

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding tenomodulin, TNMD, when comparing primary tumors of the breast to the tissue of origin, the normal breast. TNMD mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of TNMD in primary tumors of the breast was correlated with post-progression survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. TNMD may be of relevance to initiation, maintenance or progression of cancers of the female breast.