scholarly journals Over-expression of phosphatidylinositol glycan anchor biosynthesis class F in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression ◽  
Class F

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified phosphatidylinositol glycan anchor biosynthesis class F, encoded by PIGF, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PIGF was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PIGF was correlated with overall survival in black and in white patients with high mutational burden. PIGF may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of cytoskeleton associated protein 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cytoskeleton associated protein 2, encoded by CKAP2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CKAP2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CKAP2 was correlated with recurrence-free survival in white patients with high and low mutational burden. CKAP2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of CDC20 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Endometrial Cell ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cell division cycle 20, encoded by CDC20, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CDC20 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, high primary tumor expression of CDC20 was correlated with worse overall survival in white endometrial cancer patients with high mutational burden. The data allude to activation of the endometrial cell cycle in patients with endometrial cancer.

scholarly journals Over-expression of dihydrolipoamide S-acetyltransferase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified dihydrolipoamide S-acetyltransferase, encoded by DLAT, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DLAT was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DLAT was correlated with overall survival in black patients with low mutational burden. DLAT may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of denticleless E3 ubiquitin protein ligase homolog in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Ubiquitin Protein Ligase ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified denticleless E3 ubiquitin protein ligase homolog, encoded by DTL, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DTL was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DTL was correlated with overall survival in white patients with low mutational burden. DTL may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of hyaluronan mediated motility receptor in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified hyaluronan mediated motility receptor, encoded by HMMR, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. HMMR was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of HMMR was correlated with overall survival in white patients with low mutational burden. HMMR may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of thymidylate synthetase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Thymidylate Synthetase ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified thymidylate synthetase, encoded by TYMS, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. TYMS was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of TYMS was correlated with overall survival in white patients with low mutational burden. TYMS may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of keratin 18 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Keratin 18 ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published and public microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified keratin 18, encoded by KRT18, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. KRT18 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of KRT18 was correlated with overall survival in white patients with high and low mutational burden. KRT18 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of NME/NM23 nucleoside diphosphate kinase 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Nucleoside Diphosphate Kinase ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified NME/NM23 nucleoside diphosphate kinase 1, encoded by NME1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. NME1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of NME1 was correlated with overall survival in white patients with high mutational burden. NME1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of non-SMC condensin I complex subunit G in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified non-SMC condensin I complex subunit G, encoded by NCAPG, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. NCAPG was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of NCAPG was correlated with recurrence-free survival in white patients with low mutational burden. NCAPG may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ORMDL sphingolipid biosynthesis regulator 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression ◽  
Sphingolipid Biosynthesis

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published and public microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ORMDL sphingolipid biosynthesis regulator 2, encoded by ORMDL2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ORMDL2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of ORMDL2 was correlated with overall survival in white patients with low mutational burden. ORMDL2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

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