scholarly journals Over-expression of dihydrolipoamide S-acetyltransferase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified dihydrolipoamide S-acetyltransferase, encoded by DLAT, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DLAT was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DLAT was correlated with overall survival in black patients with low mutational burden. DLAT may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of cytoskeleton associated protein 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cytoskeleton associated protein 2, encoded by CKAP2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CKAP2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CKAP2 was correlated with recurrence-free survival in white patients with high and low mutational burden. CKAP2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of CDC20 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Endometrial Cell ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cell division cycle 20, encoded by CDC20, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CDC20 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, high primary tumor expression of CDC20 was correlated with worse overall survival in white endometrial cancer patients with high mutational burden. The data allude to activation of the endometrial cell cycle in patients with endometrial cancer.

scholarly journals Over-expression of phosphatidylinositol glycan anchor biosynthesis class F in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression ◽  
Class F

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified phosphatidylinositol glycan anchor biosynthesis class F, encoded by PIGF, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PIGF was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PIGF was correlated with overall survival in black and in white patients with high mutational burden. PIGF may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of MLX, MAX dimerization protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified MLX, MAX dimerization protein, encoded by MLX, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. MLX was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of MLX was correlated with recurrence-free survival in black patients with low mutational burden. MLX may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ALG8, alpha-1,3-glucosyltransferase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal and hyperplastic endometrium to endometrial tumors from humans. We identified ALG8, alpha-1,3-glucosyltransferase, encoded by ALG8, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ALG8 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of ALG8 was correlated with overall survival in black patients with low mutational burden. ALG8 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of denticleless E3 ubiquitin protein ligase homolog in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Ubiquitin Protein Ligase ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified denticleless E3 ubiquitin protein ligase homolog, encoded by DTL, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. DTL was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of DTL was correlated with overall survival in white patients with low mutational burden. DTL may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of hyaluronan mediated motility receptor in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified hyaluronan mediated motility receptor, encoded by HMMR, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. HMMR was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of HMMR was correlated with overall survival in white patients with low mutational burden. HMMR may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of NADH:ubiquinone oxidoreductase subunit A7 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Nadh:Ubiquinone Oxidoreductase ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal and hyperplastic endometrium to endometrial tumors from humans. We identified NADH:ubiquinone oxidoreductase subunit A7, encoded by NDUFA7, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. NDUFA7 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of NDUFA7 was correlated with overall survival in black patients with high mutational burden. NDUFA7 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of thymidylate synthetase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Thymidylate Synthetase ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified thymidylate synthetase, encoded by TYMS, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. TYMS was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of TYMS was correlated with overall survival in white patients with low mutational burden. TYMS may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of pyrophosphatase (inorganic) 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Black Patients ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified pyrophosphatase (inorganic) 1, encoded by PPA1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PPA1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of PPA1 was correlated with recurrence-free survival in black patients with low mutational burden. PPA1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

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