TUBE1 is a differentially expressed gene in brain metastatic human breast cancer.

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that tubulin epsilon 1, encoded by TUBE1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. TUBE1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of TUBE1 in primary tumors was significantly correlated with patient overall survival. Modulation of TUBE1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

GRHL3 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/qpnhj ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that grainyhead-like transcription factor 3, encoded by GRHL3, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. GRHL3 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of GRHL3 in primary tumors was significantly correlated with patient overall survival. Modulation of GRHL3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

RSU1 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/wsjdc ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ras suppressor protein 1, encoded by RSU1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. RSU1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of RSU1 in primary tumors was correlated with patient overall survival. Modulation of RSU1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

KRIT1 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/q4dw5 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the Krev Interaction Trapped Protein 1 (KRIT1), ankyrin repeat containing, encoded by KRIT1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. KRIT1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of KRIT1 in primary tumors was significantly correlated with patient overall survival. Modulation of KRIT1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

ABI3BP is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/b4mgz ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ABI family member 3 binding protein, encoded by ABI3BP, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ABI3BP mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of ABI3BP in primary tumors was correlated with patient overall survival. Modulation of ABI3BP expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

HOXC10 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/wh4qp ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the homeobox C10, encoded by HOXC10, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. HOXC10 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of HOXC10 in primary tumors was significantly correlated with patient overall survival. Modulation of HOXC10 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

CNTNAP3 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/q7n3a ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that contactin associated protein-like 3, encoded by CNTNAP3, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CNTNAP3 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Modulation of CNTNAP3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

TOB1 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/xpws3 ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the transducer of ERBB2, 1, encoded by TOB1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. TOB1 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of TOB1 in primary tumors was significantly correlated with patient post progression survival. Modulation of TOB1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

MICALCL is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/57ktj ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that MICAL C-terminal-like, encoded by MICALCL, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. MICALCL mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of MICALCL in primary tumors was significantly correlated with patient overall survival. Modulation of MICALCL expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

TMA16 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/572ax ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that translation machinery-associated protein 16, encoded by TMA16, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. TMA16 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Importantly, expression of TMA16 in primary tumors was correlated with patient post-progression survival. Modulation of TMA16 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.

ATG10 is a differentially expressed gene in brain metastatic human breast cancer.

10.31219/osf.io/ythxd ◽

2021 ◽

Author(s):

Shahan Mamoor

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Metastatic Breast ◽

Metastatic Tumor ◽

Clinical Problem ◽

Human Breast ◽

Primary Tumors ◽

Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that autophagy related 10, encoded by ATG10, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ATG10 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of ATG10 in primary tumors was significantly correlated with patient overall survival. Modulation of ATG10 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.