KRIT1 is a differentially expressed gene in brain metastatic human breast cancer.
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that the Krev Interaction Trapped Protein 1 (KRIT1), ankyrin repeat containing, encoded by KRIT1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. KRIT1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of KRIT1 in primary tumors was significantly correlated with patient overall survival. Modulation of KRIT1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.