scholarly journals Over-expression of CUB domain containing protein 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Cub Domain ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified CUB domain containing protein 1, encoded by CDCP1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CDCP1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CDCP1 was correlated with overall survival in endometrial cancer patients with Grade 2 tumors. CDCP1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of structural maintenance of chromosomes 4 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression ◽  
Structural Maintenance Of Chromosomes

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified structural maintenance of chromosomes 4, encoded by SMC4, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. SMC4 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of SMC4 was correlated with overall survival in patients with endometrial cancer. SMC4 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ZW10 interacting kinetochore protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Kinetochore Protein ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ZW10 interacting kinetochore protein, encoded by ZWINT, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ZWINT was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ZWINT was correlated with overall survival in patients with endometrial cancer. ZWINT may be a molecule of interest in understanding the etiology and/or progression of human endometrial cancer.

scholarly journals Over-expression of tubulin beta 4B class IVb in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Overall Survival ◽  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified tubulin beta 4B class IVb, encoded by TUBB4B, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. TUBB4B was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of TUBB4B was correlated with overall survival in patients with endometrial cancer. TUBB4B may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of adenosine kinase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Adenosine Kinase ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified adenosine kinase, encoded by ADK, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ADK was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ADK was correlated with overall survival in patients with endometrial cancer. ADK may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of KIAA0101 (PCLAF) in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified KIAA0101, also known as the PCNA clamp-associated factor (PCLAF) as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. KIAA0101 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of KIAA0101 was correlated with recurrence-free survival in patients with endometrial cancer. KIAA0101 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of epithelial splicing regulatory protein 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Regulatory Protein ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified epithelial splicing regulatory protein 1, encoded by ESRP1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ESRP1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ESRP1 was correlated with overall survival in patients with endometrial cancer. ESRP1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of adenine phosphoribosyltransferase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Adenine Phosphoribosyltransferase ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified adenine phosphoribosyltransferase, encoded by APRT, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. APRT was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of APRT was correlated with overall survival in patients with endometrial cancer. APRT may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of nucleolar and spindle associated protein 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified nucleolar and spindle associated protein 1, encoded by NUSAP1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. NUSAP1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of NUSAP1 was correlated with recurrence-free survival in patients with endometrial cancer. NUSAP1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ISG15 ubiquitin-like modifier in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ISG15 ubiquitin-like modifier, encoded by ISG15, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ISG15 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ISG15 was correlated with recurrence-free survival in patients with endometrial cancer. ISG15 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of hyaluronan mediated motility receptor in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified hyaluronan mediated motility receptor, encoded by HMMR, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. HMMR was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of HMMR was correlated with overall survival in white patients with low mutational burden. HMMR may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

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