scholarly journals Bullous Systemic Lupus Erythematosus

2018 ◽  
Vol 19 (2) ◽  
pp. 123-125
Author(s):  
Sk Jakaria Been Sayeed ◽  
Md Mujibur Rahman ◽  
AKM Humayon Kabir ◽  
Md Moniruzzaman ◽  
Uzzal Mallik ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Bullous Pemphigoid ◽  
Epidermolysis Bullosa ◽  
Lupus Erythematosus ◽  
Dermatitis Herpetiformis ◽  
Epidermolysis Bullosa Acquisita ◽  
Systemic Lupus ◽  
Type Vii Collagen ◽  
Linear Iga Disease ◽  
Distinct Disease

Bullous systemic lupus erythematosus (BSLE) is extremely rare but distinct disease, characterized by vesicobullous skin eruptions in systemic lupus erythematosus (SLE). It can develop either before or after a diagnosis of SLE has been established. BSLE is characterized by a dermatitis herpetiformis-like histology and an autoimmunity to type VII collagen. It must be differentiated from other autoimmune vesicobullous diseases such as epidermolysis bullosa acquisita, dermatitis herpetiformis, linear IgA disease, and bullous pemphigoid. Its important to combine clinical, histological, and immunofluorescence findings to establish a diagnosis of BSLE. We report a case of BSLE to illustrate and emphasize the need for an integrative diagnostic approach.J MEDICINE JUL 2018; 19 (2) : 123-125

scholarly journals Bullous systemic lupus erythematosus – a case report

2013 ◽  
Vol 22 (1) ◽  
pp. 90-92
Author(s):  
Chowdhury Mohammad Ali ◽  
SM Bakhtiar Kamal ◽  
Md Mosaraf Hossain Khan
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Epidermolysis Bullosa ◽  
Lupus Erythematosus ◽  
Dermatitis Herpetiformis ◽  
Systemic Lupus ◽  
Medical College ◽  
Type Vii Collagen ◽  
Linear Iga Disease ◽  
Distinct Disease

Bullous systemic lupus erythematosus (BSLE) is a rare but distinct disease, characterized by vesicobullous skin eruptions in systemic lupus erythematosus (SLE). It can arise either before or after a diagnosis of SLE has been established. BSLE is characterized by a dermatitis herpetiformis-like histology and an autoimmunity to type VII collagen. It must be differentiated from other autoimmune vesicobullous diseases such as epidermolysis bullosa acquisita, dermatitis herpetiformis, linear IgA disease, and bullous pemphigoid. A combination of clinical, histological, and immunofluorescence findings are necessary to establish a diagnosis of BSLE. We present a case of BSLE to illustrate and emphasize the need for an integrative diagnostic approach. DOI: http://dx.doi.org/10.3329/jdmc.v22i1.15691 J Dhaka Medical College, Vol. 22, No. 1, April, 2013, Page 90-92

Epidermolysis bullosa acquisita preceding the development of systemic lupus erythematosus

1990 ◽  
Vol 22 (4) ◽  
pp. 587-593 ◽  
Author(s):  
Erin Boh ◽  
Lynne J. Roberts ◽  
Tsu-San Lieu ◽  
W. Ray Gammon ◽  
Richard D. Sontheimer
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Epidermolysis Bullosa ◽  
Lupus Erythematosus ◽  
Epidermolysis Bullosa Acquisita ◽  
Systemic Lupus

scholarly journals Epidermolysis Bullosa Acquisita Occuring In A Patient With Systemic Lupus Erythematosus

2019 ◽  
Vol 15 (2) ◽  
pp. 100
Author(s):  
Lita Setyowatie ◽  
Yustian Devika Rahmawati ◽  
Arif Widiatmoko ◽  
Diah Prabawati Retnani
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Mhc Class Ii ◽  
Epidermolysis Bullosa ◽  
Lupus Erythematosus ◽  
Wound Care ◽  
Case Reports ◽  
Epidermolysis Bullosa Acquisita ◽  
Entire Body ◽  
Systemic Lupus ◽  
Vacuolar Degeneration

Epidermolysis Bullosa Acquisita (EBA) is a rare, chronic autoimmune subepidermal bullous disease and has been noted to be associated with systemic lupus erythematosus (SLE). The incidence of EBA and SLE in one patient within the period of 1980-1990 found only 7 published case reports. A 23 years old woman with exfoliate skin since 12 years ago. Initially itchy on her buttock then appeared small blister. Blister spread almost the entire body and rupture. This complaint got worsening in a year accompanied with hair loss, weight loss, and oral ulcer. Dermatological examination showed patch eritematosa, hyperpigmentation, hypopigmentation, erotion with erythematous base, yellow brownish crust. Also obtained sclerodactyli toes and nail fingers. Laboratory examination anemia gravis, hypoalbuminemia, Coombs test +2, ANA Test negatif, dsDNA IgG 32,80. Histopathology examination showed blister subepidermal, no vacuolar degeneration, no superficial and deep infiltrat, and minimal lymphocyte. Patient had diagnosed SLE from Internal Department based on MEX-SLEDAI score. The patient was treated with metylprednisolone intravenous pulse dose 500 mg on 3 days then tappering off and wound care. Epidermolysis Bullosa Acquisita immunogenetically related with MHC class II haplotype in particular  HLA-DR2. This factor suggest playing role in the development of  EBA to express more aggresive SLE. 

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