scholarly journals Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation

2017 ◽  
Vol 8 ◽  
Author(s):  
Tiago Veltri ◽  
Maicon Landim-Vieira ◽  
Michelle S. Parvatiyar ◽  
David Gonzalez-Martinez ◽  
Karissa M. Dieseldorff Jones ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiac Muscle ◽  
Cardiac Troponin ◽  
Troponin C ◽  
Muscle Regulation ◽  
Cardiac Troponin C ◽  
Cardiac Muscle Regulation

scholarly journals Dynamic and Structural Allosteric Events between the D/E Linker and N-Domain of Cardiac Troponin C Reveal a Novel Mechanism for Cardiac Muscle Regulation

2019 ◽  
Vol 116 (3) ◽  
pp. 488a
Author(s):  
Mayra A. Marques ◽  
Guilherme A.P. de Oliveira ◽  
Adolfo H. Moraes ◽  
Maicom Landim-Vieira ◽  
Karissa D. Jones ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Cardiac Troponin ◽  
Troponin C ◽  
Muscle Regulation ◽  
Cardiac Troponin C ◽  
Cardiac Muscle Regulation

scholarly journals Hypertrophic Cardiomyopathy-Linked Mutation D145E Drastically Alters Calcium Binding by the C-Domain of Cardiac Troponin C

Biochemistry ◽  
2010 ◽  
Vol 49 (23) ◽  
pp. 4813-4820 ◽  
Author(s):  
Nicholas Swindle ◽  
Svetlana B. Tikunova
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Calcium Binding ◽  
Cardiac Troponin ◽  
Troponin C ◽  
Cardiac Troponin C

scholarly journals A Mutation inTNNC1-encoded Cardiac Troponin C, TNNC1-A31S, Predisposes to Hypertrophic Cardiomyopathy and Ventricular Fibrillation

2012 ◽  
Vol 287 (38) ◽  
pp. 31845-31855 ◽  
Author(s):  
Michelle S. Parvatiyar ◽  
Andrew P. Landstrom ◽  
Cicero Figueiredo-Freitas ◽  
James D. Potter ◽  
Michael J. Ackerman ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Ventricular Fibrillation ◽  
Cardiac Troponin ◽  
Troponin C ◽  
Cardiac Troponin C

scholarly journals A Novel Mutation in TNNC1-ENCODED Cardiac Troponin C Predisposes to Hypertrophic Cardiomyopathy and Recurrent Episodes of Aborted Sudden Cardiac Death

2011 ◽  
Vol 100 (3) ◽  
pp. 114a
Author(s):  
Michelle S. Parvatiyar ◽  
Andrew P. Landstrom ◽  
Jose Renato Pinto ◽  
Jingsheng Liang ◽  
Michael J. Ackerman ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Sudden Cardiac Death ◽  
Cardiac Troponin ◽  
Cardiac Death ◽  
Novel Mutation ◽  
Troponin C ◽  
Cardiac Troponin C

Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility

2008 ◽  
Vol 33 (2) ◽  
pp. 257-266 ◽  
Author(s):  
Bo Liang ◽  
Franca Chung ◽  
Yang Qu ◽  
Dmitri Pavlov ◽  
Todd E. Gillis ◽  
...  
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiac Myocytes ◽  
Cardiac Troponin ◽  
Sarcomere Length ◽  
Troponin C ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Force Generation ◽  
Binding Characteristics ◽  
Cardiac Troponin C ◽  
Myocyte Contractility

The cardiac troponin C (cTnC) mutation, L29Q, has been found in a patient with familial hypertrophic cardiomyopathy. We previously showed that L29, together with neighboring residues, Asp2, Val28, and Gly30, plays an important role in determining the Ca2+ affinity of site II, the regulatory site of mammalian cardiac troponin C (McTnC). Here we report on the Ca2+ binding characteristics of L29Q McTnC and D2N/V28I/L29Q/G30D McTnC (NIQD) utilizing the Phe27 → Trp (F27W) substitution, allowing one to monitor Ca2+ binding and release. We also studied the effect of these mutants on Ca2+ activation of force generation in single mouse cardiac myocytes using cTnC replacement, together with sarcomere length (SL) dependence. The Ca2+-binding affinity of site II of L29Q McTnCF27W and NIQD McTnCF27W was ∼1.3- and ∼1.9-fold higher, respectively, than that of McTnCF27W. The Ca2+ disassociation rate from site II of L29Q McTnCF27W and NIQD McTnCF27W was not significantly different than that of control (McTnCF27W). However, the rate of Ca2+ binding to site II was higher in L29Q McTnCF27W and NIQD McTnCF27W relative to control (∼1.5-fold and ∼2.0-fold respectively). The Ca2+ sensitivity of force generation was significantly higher in myocytes reconstituted with L29Q McTnC (∼1.4-fold) and NIQD McTnC (∼2-fold) compared with those reconstituted with McTnC. Interestingly, the change in Ca2+ sensitivity of force generation in response to an SL change (1.9, 2.1, and 2.3 μm) was significantly reduced in myocytes containing L29Q McTnC or NIQD McTnC. These results demonstrate that the L29Q mutation enhances the Ca2+-binding characteristics of cTnC and that when incorporated into cardiac myocytes, this mutant alters myocyte contractility.

scholarly journals Familial Hypertrophic Cardiomyopathy (FHC)-Related Cardiac Troponin C (cTnC) L29Q Mutation Alters the Contractility and the Functional Effects of the Phosphomimetric cTnI

2012 ◽  
Vol 102 (3) ◽  
pp. 358a
Author(s):  
Alison Y. Li ◽  
Bo Liang ◽  
Sean C. Little ◽  
Jonathan Davis ◽  
Glen F. Tibbits
Keyword(s):  
Hypertrophic Cardiomyopathy ◽  
Cardiac Troponin ◽  
Troponin C ◽  
Familial Hypertrophic Cardiomyopathy ◽  
Cardiac Troponin C

The cardiac-muscle specific enhancer-promoter of slow/cardiac troponin C binds HMG-2

Gene ◽  
1997 ◽  
Vol 187 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Michael O Montgomery ◽  
Judith Litvin
Keyword(s):  
Cardiac Muscle ◽  
Cardiac Troponin ◽  
Troponin C ◽  
Cardiac Troponin C
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