First Nations Peoples, the original inhabitants of what is now the United States, are diverse and growing populations. There are approximately 5.2 million First Nations Peoples within the boundaries of the United States, accounting for 1.7% of the general population (Norris, Vines, & Hoeffel, 2012). First Nations people tend to be younger, poorer, and less educated than others in the United States. The contemporary issues faced by these peoples are intimately intertwined with the history of colonization and current federal policies that perpetuate dependency and undermine self-determination. Social workers must overcome the negative history of the profession with First Nations Peoples, in particular social work involvement in extensive child removals and coercive sterilization of Indigenous women. Social workers have the power and ability to make important differences in enhancing the social and health status of First Nations Peoples, but this must begin with an awareness of their own attitudes and beliefs, as well as an awareness of how social workers have contributed to, rather than worked to alleviate, the problems of First Nations Peoples.