Faculty Opinions recommendation of The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.

2001 ◽  
Author(s):  
Elsebet Lund
Keyword(s):  
Mrna Decay ◽  
Mrna Export ◽  
Exon Junction Complex ◽  
Exon Junction ◽  
Nonsense Mediated Mrna Decay

scholarly journals Exon-Junction Complex Components Specify Distinct Routes of Nonsense-Mediated mRNA Decay with Differential Cofactor Requirements

2005 ◽  
Vol 20 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Niels H. Gehring ◽  
Joachim B. Kunz ◽  
Gabriele Neu-Yilik ◽  
Stephen Breit ◽  
Marcelo H. Viegas ◽  
...  
Keyword(s):  
Mrna Decay ◽  
Exon Junction Complex ◽  
Exon Junction ◽  
Nonsense Mediated Mrna Decay ◽  
Complex Components

scholarly journals The Exon Junction Complex Undergoes a Compositional Switch that Alters mRNP Structure and Nonsense-Mediated mRNA Decay Activity

Cell Reports ◽  
2018 ◽  
Vol 25 (9) ◽  
pp. 2431-2446.e7 ◽  
Author(s):  
Justin W. Mabin ◽  
Lauren A. Woodward ◽  
Robert D. Patton ◽  
Zhongxia Yi ◽  
Mengxuan Jia ◽  
...  
Keyword(s):  
Mrna Decay ◽  
Exon Junction Complex ◽  
Exon Junction ◽  
Nonsense Mediated Mrna Decay

scholarly journals A Day in the Life of the Exon Junction Complex

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 866 ◽  
Author(s):  
Lena P. Schlautmann ◽  
Niels H. Gehring
Keyword(s):  
Mrna Export ◽  
Mrna Splicing ◽  
Exon Junction Complex ◽  
Chronological Order ◽  
Exon Junction ◽  
Messenger Ribonucleoprotein ◽  
Associated Proteins ◽  
Core Components ◽  
Nonsense Mediated Mrna Decay ◽  
Exon Junctions

The exon junction complex (EJC) is an abundant messenger ribonucleoprotein (mRNP) component that is assembled during splicing and binds to mRNAs upstream of exon-exon junctions. EJCs accompany the mRNA during its entire life in the nucleus and the cytoplasm and communicate the information about the splicing process and the position of introns. Specifically, the EJC’s core components and its associated proteins regulate different steps of gene expression, including pre-mRNA splicing, mRNA export, translation, and nonsense-mediated mRNA decay (NMD). This review summarizes the most important functions and main protagonists in the life of the EJC. It also provides an overview of the latest findings on the assembly, composition and molecular activities of the EJC and presents them in the chronological order, in which they play a role in the EJC’s life cycle.

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