Faculty Opinions recommendation of Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins.

2006 ◽  
Author(s):  
Susumu Tomita
Keyword(s):  
Glutamate Receptor ◽  
Receptor Function

Homer: a link between neural activity and glutamate receptor function

2000 ◽  
Vol 10 (3) ◽  
pp. 370-374 ◽  
Author(s):  
Bo Xiao ◽  
Jian Cheng Tu ◽  
Paul F Worley
Keyword(s):  
Glutamate Receptor ◽  
Neural Activity ◽  
Receptor Function

scholarly journals Zinc Potentiates GluK3 Glutamate Receptor Function by Stabilizing the Ligand Binding Domain Dimer Interface

Neuron ◽  
2012 ◽  
Vol 76 (3) ◽  
pp. 565-578 ◽  
Author(s):  
Julien Veran ◽  
Janesh Kumar ◽  
Paulo S. Pinheiro ◽  
Axel Athané ◽  
Mark L. Mayer ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Glutamate Receptor ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Receptor Function ◽  
Dimer Interface

scholarly journals Oxytocin Reduces Cocaine Seeking and Reverses Chronic Cocaine-Induced Changes in Glutamate Receptor Function

2014 ◽  
Vol 18 (1) ◽  
pp. pyu009-pyu009 ◽  
Author(s):  
L. Zhou ◽  
W.-L. Sun ◽  
A. B. Young ◽  
K. Lee ◽  
J. F. McGinty ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Receptor Function ◽  
Chronic Cocaine ◽  
Cocaine Seeking ◽  
Induced Changes

Novel Potential Therapeutics for Schizophrenia: Focus on the Modulation of Metabotropic Glutamate Receptor Function

2005 ◽  
Vol 3 (1) ◽  
pp. 9-34 ◽  
Author(s):  
Laura Chavez-Noriega ◽  
Michael Marino ◽  
Herve Schaffhauser ◽  
Una Campbell ◽  
P. Conn
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Function ◽  
Metabotropic Glutamate ◽  
Potential Therapeutics

Ethanol and glutamate receptor function

1979 ◽  
Vol 4 (5) ◽  
pp. 707 ◽  
Author(s):  
E.K. Michaelis ◽  
M.L. Michaelis ◽  
R.M. Belieu ◽  
R.D. Grubbs
Keyword(s):  
Glutamate Receptor ◽  
Receptor Function

scholarly journals Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors

2015 ◽  
Vol 112 (19) ◽  
pp. 6182-6187 ◽  
Author(s):  
Tae Hee Han ◽  
Poorva Dharkar ◽  
Mark L. Mayer ◽  
Mihaela Serpe
Keyword(s):  
Glutamate Receptors ◽  
Glutamate Receptor ◽  
Crystallographic Analysis ◽  
Channel Block ◽  
Receptor Function ◽  
Expression Systems ◽  
Excitatory Neurotransmitter ◽  
Ligand Selectivity ◽  
Heterologous Expression Systems ◽  
Larval Neuromuscular Junction

The Drosophila larval neuromuscular junction (NMJ), at which glutamate acts as the excitatory neurotransmitter, is a widely used model for genetic analysis of synapse function and development. Despite decades of study, the inability to reconstitute NMJ glutamate receptor function using heterologous expression systems has complicated the analysis of receptor function, such that it is difficult to resolve the molecular basis for compound phenotypes observed in mutant flies. We find that Drosophila Neto functions as an essential component required for the function of NMJ glutamate receptors, permitting analysis of glutamate receptor responses in Xenopus oocytes. In combination with a crystallographic analysis of the GluRIIB ligand binding domain, we use this system to characterize the subunit dependence of assembly, channel block, and ligand selectivity for Drosophila NMJ glutamate receptors.

Emerging structural explanations of ionotropic glutamate receptor function

2004 ◽  
Vol 18 (3) ◽  
pp. 428-438 ◽  
Author(s):  
Robert L. Mcfeeters ◽  
Robert E. Oswald
Keyword(s):  
Glutamate Receptor ◽  
Ionotropic Glutamate Receptor ◽  
Receptor Function
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