Faculty Opinions recommendation of Impact of preoperative statin therapy on adverse postoperative outcomes in patients undergoing cardiac surgery: a meta-analysis of over 30,000 patients.

Author(s):  
Stefan De Hert
2008 ◽  
Vol 29 (12) ◽  
pp. 1548-1559 ◽  
Author(s):  
Oliver J. Liakopoulos ◽  
Yeong-Hoon Choi ◽  
Peter L. Haldenwang ◽  
Justus Strauch ◽  
Thorsten Wittwer ◽  
...  

Author(s):  
Jaewon Chang ◽  
Janice Nathalie ◽  
Minhtuan Nguyenhuy ◽  
Ruiwen Xu ◽  
Sohaib A Virk ◽  
...  

2017 ◽  
Vol 32 (6) ◽  
pp. 518-529.e2 ◽  
Author(s):  
C. Ramesh ◽  
Baby S. Nayak ◽  
Vasudev Baburaya Pai ◽  
Nitin T. Patil ◽  
Anice George ◽  
...  

2006 ◽  
Vol 105 (6) ◽  
pp. 1260-1272 ◽  
Author(s):  
Katja Hindler ◽  
Andrew D. Shaw ◽  
Joshua Samuels ◽  
Stephanie Fulton ◽  
Charles D. Collard ◽  
...  

Statin therapy is well established for prevention of cardiovascular disease. Statins may also reduce postoperative mortality and morbidity via a pleiotropic (non-lipid-lowering) effect. The authors conducted a meta-analysis to determine the influence of statin treatment on adverse postoperative outcomes in patients undergoing cardiac, vascular, or noncardiovascular surgery. Two independent authors abstracted data from 12 retrospective and 3 prospective trials (n = 223,010 patients). A meta-analysis was performed to evaluate the overall effect of preoperative statin therapy on postoperative outcomes. Preoperative statin therapy was associated with 38% and 59% reduction in the risk of mortality after cardiac (1.9% vs. 3.1%; P = 0.0001) and vascular (1.7% vs. 6.1%; P = 0.0001) surgery, respectively. When including noncardiac surgery, a 44% reduction in mortality (2.2% vs. 3.2%; P = 0.0001) was observed. Preoperative statin therapy may reduce postoperative mortality in patients undergoing surgical procedures. However, the statin associated effects on postoperative cardiovascular morbidity are too variable to draw any conclusion.


2006 ◽  
Vol 23 (Supplement 37) ◽  
pp. 7-8
Author(s):  
K. Hindler ◽  
A. D. Shaw ◽  
J. S. Samuels ◽  
C. D. Collard ◽  
B. Riedel

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