This chapter provides a summary of the landmark study known as the FACTT Trial. Does a conservative versus liberal fluid-management protocol reduce death from any cause at 60 days in patients with acute lung injury? Starting with that question, the chapter describes the basics of the study, including funding, study location, who was studied, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, discusses implications, and concludes with a relevant clinical case. Although conservative fluid management in patients with acute lung injury had a similar profile with respect to adverse events as did a liberal fluid management, the conservative fluid strategy did improve lung function and shorten the duration of mechanical ventilation and intensive care length of stay.
Comparison of two fluid-management strategies in acute lung injury
