Comparative Analysis of Retinal Nerve Fiber Layer Thickness between Normal and Mild to Moderately Myopic Eyes

Purpose: To determine the difference between mean retinal nerve fiber layer (RNFL) thickness in myopic eyes (up to -6.00D) and normal eyes. Study Design: Descriptive observational study. Place and Duration of the Study: Eye department of Mayo hospital Lahore, from February 2019 to April 2019. Methods: We compared the mean RNFL between 58 myopic eyes (up to -6.00 D) and age matched 60 normal eyes. The age of the participants was between 12 to 42 years. Complete ocular examination was done and RNFL thickness was measured by using Optical coherence tomography (NIDEX RS-33.0, software-ex 1.5.2).Data was analyzed by independent sample t-test by using SPSS; with P < .05 as significant. Results: The mean difference among these groups was 5.852 µm with (SE: 1.929). Mean RNFL thickness in myopic group was (95.93 ± 10.158µm) with (SE: 1.334). The result for mean RNFL thickness in myopic eyes was distributed normally as P < .03. Mean RNFL in normal group was (101.78 ± 10.774 µm) with (SE: 1.391), and the result of mean RNFL thickness measured in normal eyes was not distributed normally as P < .20. The results showed that there is a statistically significant difference between mean RNFL thickness measured in normal versus myopic eyes as (P < .003). Conclusion: There is a significance difference between mean RNFL thickness between myopic eyes and normal eyes as measured by OCT. Careful interpretation of RNFL data in myopic eyes is recommended to avoid misdiagnosis with glaucoma. Key Words: Retinal Nerve Fiber Layer thickness, Myopia, Optical Coherence Tomography.

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To evaluate the retinal nerve fiber layer thickness in different types of glaucoma

Advances in Ophthalmology & Visual System ◽

10.15406/aovs.2021.11.00400 ◽

2021 ◽

Vol 11 (1) ◽

pp. 5-9

Author(s):

Aqsa Batool ◽

Iqra Nehal ◽

Areej Riaz ◽

Muzna Javed ◽

Tahir Hussain ◽

...

Keyword(s):

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Physical Damage ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Rnfl Thickness ◽

The Mean ◽

Retinal Nerve Fiber

Objective: Glaucoma is a multifaceted eye disease which is classified as physical damage of retinal ganglion cells which may effect in loss of vision and permanent blindness. While physical damage of glaucoma can be clinically evaluated the optic nerve head and peripapillary retinal nerve fiber layer (RNFL). Our objective is to evaluate the mean RNFL thickness in all types of glaucoma. Methodology: This prospective and cross sectional study was conducted in Glaucoma Clinic of Al Ibrahim Eye Hospital (AIEH), Karachi, for the period from May 2019 to October 2019, after ethical approval from Institutional Research Committee. A total of 64 glaucoma patients were chosen by using non-probability purposive sampling technique. The participant comprised, no known eye disease, no visual impairment, IOP below 22 mmHg, and no obvious retinal disease or defect were included while individuals having a history of ocular diseases or pathology with residual visual impairment, retinal diseases, amblyopia, and history of intraocular surgery or laser therapy were excluded from the study. The collected data were analyzed using Statistical Package for Social Sciences (SPSS) version 20. Results: 64 patients of both genders with mean age of 55.54±15.58 years. The mean intraocular pressure of right eye and left eye was 16.46±8.06 and 16.75±7.82 mmHg, respectively. The mean RNFL thickness in superior, inferior, temporal and nasal quadrant of the right eye was measured 68.23±25.44, 66.79±27.50, 51.75±12.58 and 47.73±18.82 microns, respectively while the mean RNFL thickness in superior, inferior, temporal and nasal quadrant of the left eye was measured 76.01±22.72, 67.42±21.25, 54.37±13.0 and 49.62±11.57 microns, respectively. Conclusion: Our study showed that analysis of retinal nerve fiber layer thickness with optical coherence tomography is the best tool for the diagnosis of glaucoma. It has also been observed in our study that frequency of changes in retinal nerve fiber layer thickness was mostly found in primary open angle glaucoma patients

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Comparison of Quadrantic Retinal Nerve Fiber Layer Thickness between Glaucoma Patients and Age Matched Controls

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v37i3.1199 ◽

2021 ◽

Vol 37 (3) ◽

Author(s):

Nargis Nizam Ashraf ◽

Nisar Ahmed Siyal ◽

Muhammad Ibrahim

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

The Mean ◽

Retinal Nerve Fiber

Purpose: To compare the quadrantic retinal nerve fiber layer thickness between the glaucoma patients and age-matched controls. Study Design: Descriptive observational study. Place and Duration of study: Eye Department of Civil Hospital Karachi, from January 2018 to December 2020. Methods: Two hundred and fifty eyes were included in this study. There were 128 eyes of the glaucoma patients and 122 eyes were age-matched controls. After complete ocular examination, all participants underwent optical coherence tomography and retinal nerve fiber layer thickness measurement in four quadrants. Prior quadrants were subsequently analyzed. Heidelberg 3-D optical coherence tomography 2017, Spec- TR- 04859 was used. Readings were saved on Excel sheet and analyzed on SPSS version 25. For descriptive statistics the mean and standard deviations were calculated for each quadrant and for inferential statistics the data was first checked for the normality. Comparison of the quadrants was done using non-parametric Paired Sample t-test (Wilcoxon signed rank test). Results: Out of 250. Form which 128 (51%) eyes were those of glaucoma patients and 122 (49%) eyes were of non-glaucoma patients. The mean difference between the Glaucomatous and non-Glaucomatous eyes were statistically significant in all four quadrants (p > 0.05). Conclusion: Glaucomatous eyes had reduced RNFL thickness in all quadrants. The thickness of the inferior quadrant was more as compared to the other quadrants in both glaucoma and control groups. Whereas the least thickness was that of the temporal quadrant. Key Words: Retinal nerve fiber layer, Optical coherence tomography, Glaucoma.

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Faculty Opinions recommendation of Automated segmentation errors when using optical coherence tomography to measure retinal nerve fiber layer thickness in glaucoma.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726937566.793525178 ◽

2016 ◽

Author(s):

Julian Garcia-Feijoo ◽

Federico Saenz-Frances

Keyword(s):

Optical Coherence Tomography ◽

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Automated Segmentation ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Retinal Nerve Fiber

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Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography

Multiple Sclerosis Journal ◽

10.1177/1352458508091367 ◽

2008 ◽

Vol 14 (7) ◽

pp. 893-905 ◽

Cited By ~ 126

Author(s):

F Costello ◽

W Hodge ◽

YI Pan ◽

E Eggenberger ◽

S Coupland ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Neuritis ◽

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Optical Coherence ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Retinal Nerve Fiber

Introduction Optic neuritis causes retinal nerve fiber layer damage, which can be quantified with optical coherence tomography. Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis. Methods This prospective case series included 78 patients with optic neuritis, who underwent optical coherence tomography and visual testing over a mean period of 28 months. The main outcome measures included comparing inter-eye differences in retinal nerve fiber layer thickness between clinically affected and non-affected eyes over time; establishing when RNFL thinning stabilized after optic neuritis; and correlating retinal nerve fiber layer thickness and visual function. Results The earliest significant inter-eye differences manifested 2-months after optic neuritis, in the temporal retinal nerve fiber layer. Inter-eye comparisons revealed significant retinal nerve fiber layer thinning in clinically affected eyes, which persisted for greater than 24 months. Retinal nerve fiber thinning manifested within 6 months and then stabilized from 7 to 12 months after optic neuritis. Regression analyses demonstrated a threshold of nerve fiber layer thickness (75μm), which predicted visual recovery after optic neuritis. Conclusions Retinal nerve fiber layer changes may be tracked and correlated with visual function within 12 months of an optic neuritis event.

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