scholarly journals Fluid resuscitation in acute pancreatitis: Normal saline or lactated Ringer's solution?

2015 ◽  
Vol 21 (31) ◽  
pp. 9367 ◽  
Author(s):  
Michal Lipinski



Pancreatology ◽  
2018 ◽  
Vol 18 (5) ◽  
pp. 507-512 ◽  
Author(s):  
Sararak Choosakul ◽  
Kamin Harinwan ◽  
Sakkarin Chirapongsathorn ◽  
Krit Opuchar ◽  
Theeranun Sanpajit ◽  
...  


2020 ◽  
Vol 158 (6) ◽  
pp. S-166
Author(s):  
Alice A. Lee ◽  
Carlos Buitrago ◽  
Christopher Ko ◽  
Brent Hiramoto ◽  
Liam Hilson ◽  
...  


2021 ◽  
Vol 29 (22) ◽  
pp. 1292-1297
Author(s):  
You-You Gu ◽  
Jue-Lei Wang ◽  
Zong-Nan Chen ◽  
Su Wang ◽  
Xiao-Zhi Liu




2002 ◽  
Vol 94 (2) ◽  
pp. 378-384 ◽  
Author(s):  
Joachim Boldt ◽  
G. Haisch ◽  
S. Suttner ◽  
B. Kumle ◽  
F. Schellhase




2017 ◽  
Vol 6 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Enrique de-Madaria ◽  
Iván Herrera-Marante ◽  
Verónica González-Camacho ◽  
Laia Bonjoch ◽  
Noé Quesada-Vázquez ◽  
...  

Background Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP). Objective The objective of this article was to compare the effect of lactated Ringer’s solution (LR) vs normal saline (NS) in the inflammatory response in AP. Methods We conducted a triple-blind, randomized, controlled trial. Patients ≥ 18 admitted with AP were eligible. Patients were randomized to receive LR or NS. Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours. In vitro complementary experiments were performed to further explore the interaction between pH, lactate and inflammation. Results Nineteen patients receiving LR and 21 receiving NS were analyzed. The median (p25–p75) number of SIRS criteria at 48 hours were 1 (1–2) for NS vs 1 (0–1) for LR, p = 0.060. CRP levels (mg/l) were as follows: at 48 hours NS 166 (78–281) vs LR 28 (3–124), p = 0.037; at 72 hours NS 217 (59–323) vs LR 25 (3–169), p = 0.043. In vitro, LR inhibited the induction of inflammatory phenotype of macrophages and NF-κB activation. This effect was not observed when using Ringer’s solution without lactate, suggesting a direct anti-inflammatory effect of lactate. Conclusions Lactated Ringer’s is associated with an anti-inflammatory effect in patients with acute pancreatitis.



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