scholarly journals Effect of a beta-blocker, celiprolol, on circadian variation in blood pressure and hemodynamics of essential hypertension.

Author(s):  
FUJIO DEGUCHI
1982 ◽  
Vol 63 (2) ◽  
pp. 19-21
Author(s):  
Yu. A. Panfilov ◽  
N. N. Kryukov ◽  
E. D. Baibursyan

Abstract. Depending on the hemodynamic type and state of the kallikreinkinin 'blood system, differential treatment of 246 hypertensive patients was carried out using the beta-blocker anaprilin and the peripheral arteriolar vasodilator apressin. A pronounced hypotensive effect was observed in 82.5% of patients. In patients who underwent differential treatment, a decrease in blood pressure was observed 3.2 days earlier than in patients who were treated empirically; hospitalization terms were reduced by an average of 2.5 bed-days.


1973 ◽  
Vol 1 (2) ◽  
pp. 462-464
Author(s):  
Ann Dawson ◽  
Ian Smith ◽  
Brian F Johnson

In seven hypertensives receiving beta-blocker drugs, an additional reduction in standing blood pressure occurred between 60 and 90 minutes after 40 mg phentolamine by mouth. The occurrence of the postural hypotensive effect was delayed in relation to the reported time of peak plasma concentration of unchanged phentolamine. Supine blood pressure and heart rate were unaffected. Phentolamine has no clinically useful anti-hypertensive effect in conjunction with beta-blockers in patients with essential hypertension.


1987 ◽  
Vol 10 ◽  
pp. S108-S112 ◽  
Author(s):  
Toshio Ogihara ◽  
Masao Ikeda ◽  
Yuichiro Goto ◽  
Kaoru Yoshinaga ◽  
Yuichi Kumahara ◽  
...  

1984 ◽  
Vol 12 (4) ◽  
pp. 221-228 ◽  
Author(s):  
G Muiesan ◽  
C Alicandri ◽  
E Agabiti-Rosei ◽  
R Fariello ◽  
E Montini ◽  
...  

Thirty-two patients with moderate to severe essential hypertension whose supine diastolic blood pressure (SDBP) was ⩾95 mm Hg following 2 weeks' treatment with the optimal dosage of beta blocker-diuretic combination were randomly assigned to the addition of either Captopril 25 mg or 50 mg b.i.d. After 6 weeks' treatment, if patients were not normalized (SDBP <95 mm Hg), the dose of Captopril was doubled for a further 6 weeks. The addition of Captopril led to a significant fall in standing and supine diastolic and systolic blood pressure at the end of the sixth and twelfth week of treatment. There was no difference in the change in blood pressure between the two groups. At the end of the study SDBP was normalized in 66% of patients and a further 12·5% had their SDBP reduced by >10%. Captopril 25 or 50 mg administered twice daily proved to be a very effective antihypertensive agent when added to a beta blocker-diuretic combination in patients resistant to optimal doses of these drugs.


1987 ◽  
Vol 10 ◽  
pp. S108-S112
Author(s):  
Toshio Ogihara ◽  
Masao Ikeda ◽  
Yuichiro Goto ◽  
Kaoru Yoshinaga ◽  
Yuichi Kumahara ◽  
...  

1978 ◽  
Vol 55 (s4) ◽  
pp. 391s-393s ◽  
Author(s):  
Michael W. Millar Craig ◽  
Stewart Mann ◽  
V. Balasubramanian ◽  
E. B. Raftery

1. Both systolic and diastolic blood pressure show a well defined circadian variation in ambulatory hypertensive subjects. 2. Blood pressure is highest in the mid-morning (10.00 hours) and lowest during sleep at 03.00 hours. 3. Treatment with oxprenolol (taken during the day) reduces daytime blood pressure but is less effective during the night and early morning.


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