Pilomatrix Carcinoma: A Case Report

Author(s):  
Eluecque H
2020 ◽  
Vol 6 ◽  
pp. 2513826X1989883
Author(s):  
Sarah L. Zhu ◽  
David Choi ◽  
Jenny Santos ◽  
Bernard S. Jackson ◽  
Matthew McRae

This is the first report of pilomatrix carcinoma in a man with C282Y myotonic dystrophy type 1. This pilomatrix carcinoma had originally presented as a rapidly growing recurrence of a histopathologically confirmed pilomatrixoma, removed a year prior. On examination, the fungating mass had measured 10 × 23 cm. A wide local resection with removal of suspicious lymph nodes was preformed, and the resulting defect was reconstructed with a latissimus dorsi myocutaneous flap and skin graft. Histologic investigation of the excised mass confirmed the diagnosis of pilomatrix carcinoma. This is the first reported case of pilomatrix carcinoma in a patient with a genetic condition that often presents with scalp pilomatrixomas. Potential implications of myotonic dystrophy on developing pilomatrix carcinoma are discussed.


2011 ◽  
Vol 37 (12) ◽  
pp. 1798-1805 ◽  
Author(s):  
Jeffrey M. Melancon ◽  
Wynnis L. Tom ◽  
Robert A. Lee ◽  
Michelle Jackson ◽  
Shang I. Brian Jiang

2015 ◽  
Vol 10 (1) ◽  
pp. 313-316 ◽  
Author(s):  
JI-FENG LIU ◽  
BIN LI ◽  
ZI-XUAN FAN ◽  
TING JIAO ◽  
CHAO LI ◽  
...  

Pathology ◽  
2001 ◽  
Vol 33 (2) ◽  
pp. 248-251 ◽  
Author(s):  
Ruma Dutta ◽  
Ross Boadle ◽  
Thomas Ng

2021 ◽  
pp. 98-102
Author(s):  
Meina Missak ◽  
Aaron Haig ◽  
Manal Gabril

Pilomatrixoma is an uncommon, benign tumor with differentiation towards both the hair matrix and cells arising in the cortex, most frequently appearing in the first or second decade of life. In rare instances, pilomatrixomas can show malignant transformation. Pilomatrix carcinoma is extremely uncommon and has traditionally been considered a tumor of low malignant potential; however, a high local recurrence rate has been reported. There is a paucity of literature on these lesions, with only a few reports describing the spectrum of malignant changes seen in these lesions. In this case report, we present a case of pilomatrixoma in an adult patient showing atypical features. While the tumor is small, there are focal features that suggest progression to malignancy, but do not fulfill the criteria for pilomatrix carcinoma. These focal atypical features include a focal infiltrative pattern at the periphery, with a variable cytological atypia and an increased mitotic rate, up to five mitotic events/high-power field. Irregular foci of central necrosis (comedonecrosis) were present in several lobules. Some of the features identified were similar to a subset of pilomatrixoma, known as “proliferating pilomatrixoma.” However, our case did not have the diffuse changes or larger size that has been frequently reported in “proliferating pilomatrixoma.” In conclusion, given the lack of focality of the changes, the lesion in our case is best described as a pilomatricoma with atypical features. Furthermore, our case may highlight the need to ensure close clinical follow-up for these lesions with unexpected atypical features that raise concern of recurrence and malignant transformation.


2010 ◽  
Vol 33 (3) ◽  
pp. 272-277 ◽  
Author(s):  
Sanjay Yadia ◽  
Ciro G. Randazzo ◽  
Sajjad Malik ◽  
Eric Gressen ◽  
Moshe Chasky ◽  
...  

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