scholarly journals Characterization of serum complement activity in serum of the Komodo dragon (<i>Varanus komodoensis</i>)

2012 ◽  
Vol 02 (04) ◽  
pp. 353-359 ◽  
Author(s):  
Mark Merchant ◽  
Danyell Henry ◽  
Rodolfo Falconi ◽  
Becky Muscher ◽  
Judith Bryja
2010 ◽  
Vol 133 (2-4) ◽  
pp. 165-169 ◽  
Author(s):  
Mark Merchant ◽  
Justin McFatter ◽  
Stephanie Mead ◽  
Charles McAdon ◽  
Joe Wasilewski

1984 ◽  
Vol 143 (3) ◽  
pp. 315-318
Author(s):  
KAZUO FUKUDA ◽  
JIN SEINO ◽  
TAKAO SAITO ◽  
KEI YAMAKAGE ◽  
YOSHIO KYOGOKU ◽  
...  

1972 ◽  
Vol 10 (1) ◽  
pp. 4-8
Author(s):  
Hossam E. Fadel ◽  
M. Diaa Eldin Soliman ◽  
M. M. El-Mehairy

1967 ◽  
Vol 132 (4) ◽  
pp. 282-285 ◽  
Author(s):  
Bernard J. Fogel ◽  
William A. Hook ◽  
Edwin Polish

1969 ◽  
Vol 47 (5) ◽  
pp. 547-552 ◽  
Author(s):  
Thomas S. S. Mao ◽  
Joseph J. Noval ◽  
Paul Pellerin ◽  
Otto J. Plescia

The hemolytic titers of human and guinea pig sera were greatly reduced by pretreatment with any of several phenothiazines. The anti-complement activity of the phenothiazines depended on the nature of substituents at positions 2 and 10. In the promazine group, the relative effectiveness of the position-2 substituents was in the order H > Cl > OCH3 > CF3. The presence of a piperazinyl group in the chain at position 10 conferred strong anti-complement activity. Thioridazine was the most potent inhibitor among the 12 phenothiazines studied. Complement components C′2 and C′4 in both human and guinea pig sera were more sensitive than other components to inactivation by phenothiazines. Phenothiazines administered orally in moderate doses did not lower the complement level of serum in three subjects. There was no correlation between anti-complement activity of the phenothiazines and their relative therapeutic potency.


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