The paper presents the compositions De Profundis for solo accordion, Et Exspecto for solo accordion and In Croce for accordion and cello, by one of the today’s highly appreciated composers, Sofia Gubaidulina. De Profundis is the first work by Gubaidulina for solo accordion, composed in 1978. In this work, Gubaidulina changed the ordinary sound of the accordion that she encountered in the Russian folk music, so that the sound of the accordion acquired a brand new dimension. Et Exspecto is the composition written in 1985 and has five movements. The composer expresses herself through different techniques and effects: air release valve, fast passages, tremolos, moving and static clusters, clusters by a trembling hand with a vibrato effect, etc. In Croce is a composition written in 1979 for cello and organ dedicated to the cellist Vladimir Tonkha. Gubaidulina, together with the accordion professor and artist Elsbeth Moser, rearranged In Croce for cello and accordion in 1991. The composition rests on specific crisscrossing of melodic lines, and it creates a visual impression of a cross with the listeners.