Supply chain transformation is necessary for the survival and growth of an organization; the more effective the transformation, the more likely the company is to thrive. In response to the dramatic changes in the business landscape over the last few years, many companies are launching business transformation programs to drive sweeping changes in their supply chain processes. These transformations are required to match the ever-growing customer demand and drive competition in the market. The supply chain transformation can be evident in exploring new sourcing networks, establishing collaborative forecasting processes, optimizing networks and inventories, reducing supply chain complexities, improving margins, etc. In today's world, it is no longer an option whether or not to opt for supply chain business transformations. Instead, it is a strategic mandate in order to stay relevant in the industry. This chapter provides the analysis of the most common transformation failures and suggests a practical framework leveraging some of the best practices in change management.