scholarly journals The Hannover Unified Biobank (HUB) – Centralized Standardised Biobanking at Hannover Medical School

2021 ◽  
Vol 8 ◽  
Author(s):  
Verena Kopfnagel ◽  
Inga Bernemann ◽  
Norman Klopp ◽  
Markus Kersting ◽  
Nataliia Nizhegorodtseva ◽  
...  
Keyword(s):  
Medical School ◽  
Hannover Medical School

Adenylate-Cyclase VI Transforms Ventricular Cardiomyocytes Into Biological Pacemaker Cells

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Arjang Ruhparwar
Keyword(s):  
Adenylate Cyclase ◽  
Medical School ◽  
Pacemaker Cells ◽  
Hannover Medical School ◽  
Ventricular Cardiomyocytes ◽  
Biological Pacemaker

Abstract 1744 Arjang Ruhparwar, Klaus Kallenbach, Univ of Heidelberg, Heidelberg, Germany; Gunnar Klein, Mahyar E Makoui, Christoph Bara, Hannover Medical School, Hannover, Germany; Daniel C Sigg, Medtronic Inc., Minneapolis, MN; Axel Haverich, Hannover Medical School, Hannover, Germany; Matthias Karck, University of Heidelberg, Heidelberg, Germany; Michael Niehaus, Hannover Medical School, Hannover, Germany Arjang Ruhparwar, 2007 Finalist and Presenting Author

scholarly journals Chemosaturation with percutaneous hepatic perfusion is effective in patients with ocular melanoma and cholangiocarcinoma

2020 ◽  
Vol 146 (11) ◽  
pp. 3003-3012 ◽  
Author(s):  
Leon Schönfeld ◽  
Jan B. Hinrichs ◽  
Steffen Marquardt ◽  
Torsten Voigtländer ◽  
Cornelia Dewald ◽  
...  
Keyword(s):  
Medical School ◽  
Liver Tumors ◽  
Interventional Procedure ◽  
Venous Blood ◽  
Hepatic Metastases ◽  
Ocular Melanoma ◽  
Liver Malignancies ◽  
Hannover Medical School ◽  
Hepatic Perfusion ◽  
Percutaneous Hepatic Perfusion

Abstract Background Chemosaturation with percutaneous hepatic perfusion (CS-PHP; Hepatic CHEMOSAT® Delivery System; Delcath Systems Inc, USA) is a novel interventional procedure, which delivers high doses of melphalan directly to the liver in patients with liver tumors while limiting systemic toxicity through hemofiltration of the hepatic venous blood. We have previously shown promising efficacy for patients with ocular melanoma (OM) and cholangiocarcinoma (CCA) within our single-center and multi-center experiences. The aim of this study was to analyze the safety and efficacy of CS-PHP after 141 treatments at Hannover Medical School, Germany. Methods Overall response rates (ORR) were assessed according to Response Evaluation Criteria In Solid Tumors (RECIST1.1). Median Overall survival (mOS), median progression-free survival (mPFS), and median hepatic PFS (mhPFS) were analyzed using the Kaplan–Meier estimation. Results Overall, 60 patients were treated with CS-PHP in the salvage setting from October 2014 until January 2019 at Hannover Medical School with a total of 141 procedures. Half of the patients were patients with hepatic metastases of ocular melanoma (OM) (n = 30), 14 patients had CCA (23.3%), 6 patients had hepatocellular carcinoma (10%), and 10 patients were treated for other secondary liver malignancies (16.7%). In total, ORR and disease stabilization rate were 33.3% and 70.3% (n = 25), respectively. ORR was highest for patients with OM (42.3%), followed by patients with CCA (30.8%). Independent response-associated factors were normal levels of lactate dehydrogenase (odds ratio (OR) 13.7; p = 0.015) and diagnosis with OM (OR 9.3; p = 0.028). Overall, mOS was 9 months, mPFS was 4 months, and mhPFS was 5 months. Patients with OM had the longest mOS, mPFS, and mhPFS with 12, 6, and 6 months, respectively. Adverse events included most frequently significant, but transient, hematologic toxicities (80% of grade 3/4 thrombopenia), less frequently hepatic injury up to liver failure (3.3%) and cardiovascular events including two cases of ischemic insults (5%). Conclusion Salvage treatment with CS-PHP is safe and effective particularly in patients OM and CCA. Careful attention should be paid to possible, serious hepatic, and cardiovascular complications.

scholarly journals Introducing Fellowship Programs: Cardiovascular Nuclear Imaging at Hannover Medical School, Germany

2015 ◽  
Vol 1 (1) ◽  
pp. 98-102 ◽  
Author(s):  
Frank M. Bengel ◽  
James T. Thackeray
Keyword(s):  
Medical School ◽  
Nuclear Imaging ◽  
Hannover Medical School ◽  
Fellowship Programs

Normothermic perfusion of donor lungs for preservation and evaluation using the OCS device – the first 10 patients at Hannover Medical School

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
G Warnecke ◽  
I Tudorache ◽  
C Kuehn ◽  
M Avsar ◽  
B Wiegmann ◽  
...  
Keyword(s):  
Medical School ◽  
Hannover Medical School ◽  
Normothermic Perfusion

Introduction and evaluation of a modular seminar system in gross anatomy teaching at the hannover medical school

2000 ◽  
Vol 182 (4) ◽  
pp. 393-396 ◽  
Author(s):  
Oktay Tutarel ◽  
Wolf Luedemann ◽  
Cordula Poulsen Nautrup ◽  
Kirsten Jahn ◽  
Mikosch Wilke ◽  
...  
Keyword(s):  
Medical School ◽  
Gross Anatomy ◽  
Hannover Medical School ◽  
Anatomy Teaching

scholarly journals Defining Learning Outcomes as a Prerequisite of Implementing a Longitudinal and Transdisciplinary Curriculum with Regard to Digital Competencies at Hannover Medical School

2021 ◽  
Vol 8 ◽  
pp. 238212052110283
Author(s):  
Nilufar Foadi ◽  
Christian Koop ◽  
Marie Mikuteit ◽  
Volker Paulmann ◽  
Sandra Steffens ◽  
...  
Keyword(s):  
Medical School ◽  
Learning Outcomes ◽  
Medical Curriculum ◽  
Interdisciplinary Collaboration ◽  
Group Analysis ◽  
Hannover Medical School ◽  
Project Group ◽  
Scope Of Application ◽  
Digital Competencies ◽  
Transformation Processes

Background: Worldwide educational programs face the challenge how to define and integrate digital competencies in medical education. This article describes the implementation of learning outcomes with respect to digital competencies in the compulsory curriculum at Hannover Medical School (MHH). Methods: An interdisciplinary MHH project group was constituted consisting of physicians and experts in medical informatics and in curriculum development. Over the course of 7 work sessions the group compared different international and national frameworks dealing with digital competencies for physicians. By a consensus driven approach the working group drew up a collection of learning outcomes which were regarded relevant to be incorporated in the curriculum at MHH. Results: The analysis of different frameworks indicated that data literacy is a central domain within all viewed preexisting catalogs. During the course of the project group analysis, 57 learning outcomes with respect to digital competencies were identified as necessary to be integrated in the compulsory curriculum. They were divided in 5 main categories: “handling of medical data,” “the digital infrastructure of the health system,” “scope of application: usage in patient care and in the field of preventive medicine,” “medico-legal and ethical basics,” and “transformation processes in medicine due to digitalization.” Conclusions: The MHH project group concluded that medical students should be taught digital competencies that enable an understanding of underlying functional principles of digital systems rather than their correct utilization. The presented project indicates that a close interdisciplinary collaboration of physicians and medical informaticians can be a promising approach to incorporate digital competencies in the undergraduate medical curriculum.

scholarly journals Pesquisa qualitativa: a tensão entre a arte e o método?

Idéias ◽  
2014 ◽  
Vol 4 ◽  
pp. 235
Author(s):  
Igor Cavallini Johansen
Keyword(s):  
Medical School ◽  
Hannover Medical School ◽  
University Of Berlin ◽  
Alice Salomon

Fomos brindados recentemente com a terceira edição do livro cuja leitura já se tornou obrigatória entre os estudantes de Ciências Sociais e das ciências humanas de maneira geral: “Introdução à Pesquisa Qualitativa”, de Uwe Flick. Apesar do título modesto, que sugere ser esta uma pequena introdução, o livro tem mais de 400 páginas e passa ao largo de uma revisão superfi cial. O autor é psicólogo e sociólogo, professor titular de pesquisa qualitativa na Alice Salomon University, em Berlim, Alemanha. Flick também é professor auxiliar na Free University of Berlin na área de métodos qualitativos e avaliação e é ainda professor adjunto e chefe do Departamento de Sociologia Médica da Hannover Medical School. Tem como principais interesses de pesquisa os métodos qualitativos, as representações sociais nas áreas da saúde individual e pública e a mudança tecnológica na vida cotidiana. 

Targeting FGFR2 in advanced cholangiocarcinoma: an interview with Arndt Vogel

2020 ◽  
Vol 16 (30) ◽  
pp. 2373-2374
Author(s):  
Arndt Vogel
Keyword(s):  
Medical School ◽  
Hannover Medical School ◽  
Senior Consultant ◽  
Senior Editor

Professor Arndt Vogel, a senior consultant and professor of gastrointestinal oncology in the Department of Gastroenterology, Hepatology and Endocrinology at Hannover Medical School, Germany, speaks with Rachel Jenkins (Senior Editor of Oncology Central) about cholangiocarcinoma, the challenges of the field and some promising avenues for therapy. To listen to the full podcast interview, visit Oncology Central ( www.oncology-central.com/ ) now.

The Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Germany

2020 ◽  
Vol 41 (15) ◽  
pp. 1459-1461
Author(s):  
Sabine Kafert-Kasting ◽  
Thomas Thum
Keyword(s):  
Medical School ◽  
Therapeutic Strategies ◽  
Hannover Medical School
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