NAMING DISORDERS IN LOGOPENIC VARIANT OF PRIMARY PROGRESSIVE APHASIA

2019 ◽  
Vol 17 (1) ◽  
pp. 87-95
Author(s):  
Justyna Antczak-Kujawin

Language functions, particularly disordered lexical skills were diagnosed in the examined woman based on selected diagnostic tests of the Boston Diagnostic Aphasia Examination (BDAE). Furthermore, an experimental version of the author's original test for assessing lexical-semantic performance in dementia was used. The author presents a case study of a 79-year-old woman diagnosed with logopenic variant primary progressive aphasia (lvPPA) secondary to Alzheimer’s disease. The author describes the symptoms of anomie manifested by the study participant and the supplementary strategies she applied in the case of lexical deficits. The analysis of the findings obtained in the course of language function assessment allowed the author to assess the fluency of speech, speech comprehension, repetition and naming. The study participant diagnosed with lvPPA was observed to manifest the following: an absence of motor speech disorders, absence of characteristics of evident agrammatism, preserved comprehension of individual words, preserved semantic knowledge of objects, disordered retrieval of words in spontaneous speech and in attempts to name, and disordered repetition of sentences and phrases. The analysis of the discussed case study allowed the author to discuss the progressive lexical deficits manifested by the lvPPA patient and to record those supplementary strategies that were most frequently applied in the lexical difficulties experienced by the female patient diagnosed with lvPPA.

2020 ◽  
Vol 54 (3) ◽  
pp. 113-119
Author(s):  
Lana Jerkić ◽  
Dragan Pavlović ◽  
Mile Vuković ◽  
Jelena Todorović ◽  
Mirna Zelić

Primary progressive aphasia (PPA) includes a group of neurodegenerative disorders that are characterized by progressive deterioration of language functions, while other cognitive functions, at least at the onset of the disease, are relatively spared. There are three basic subtypes of PPA: the nonfluent progressive aphasia (nvPPA), the semantic variant of a primary progressive aphasia (svPPA), and the logopenic progressive aphasia (lvPPA). The semantic variant of a PPA can also be found in the literature under the term of semantic dementia. It is clinically manifested by progressive deterioration of semantic knowledge, fluent aphasia, impaired naming and comprehension, prosopagnosia and surface dyslexia and dysgraphia (in languages with irregular orthography). As the disease progresses, other cognitive changes can be observed. The main cause of the disorder is progressive bilateral atrophy of the anterior temporal lobes, which is more manifested in the left hemisphere. The literature is modest in terms of the use of specific treatment methods in the rehabilitation of these patients. Since speech and language disorders are the most conspicuous symptom, at least at the beginning of the disease, the role of speech therapists in the assessment and restitution of speechlanguage and communication skills is also indisputable.


Cortex ◽  
2021 ◽  
Vol 140 ◽  
pp. 66-79
Author(s):  
Anja Staiger ◽  
Matthias L. Schroeter ◽  
Wolfram Ziegler ◽  
Theresa Schölderle ◽  
Sarah Anderl-Straub ◽  
...  

2020 ◽  
Vol 35 (6) ◽  
pp. 969-969
Author(s):  
Kurniadi N ◽  
Davis J

Abstract Objective The semantic, logopenic, and nonfluent/aggramatic variants of primary progressive aphasia (PPA) have distinct clinical profiles. However, much overlap exists and many questions remain regarding the nature of language impairments in each variant. This case study seeks to contribute to our understanding of the neuropsychological profile, syntactic, and phonological processes involved in logopenic variant PPA (lvPPA). Method The current case study was of a 66-year old female who gradually developed symptoms consistent with lvPPA during the prior four-year period, with marked worsening in the last few months. A collateral informant indicated that she was independent for basic and advanced activities of daily living. Brain/head imaging had not been conducted; medical history was unremarkable. Results Speech was notable for frequent pauses due to word-finding difficulty, circumlocution, and impaired naming, repetition, and verbal abstraction; fluency and comprehension were intact. Test data revealed significant impairments in tasks mediated by language including verbal processing speed, semantic knowledge, phonemic and semantic fluency, verbal learning and memory, verbal set-shifting, and judgment. Comprehension, non-verbal attention and processing speed, recognition for visual information, and performance on tasks of non-verbal executive functioning were intact. Depression and anxiety were denied. Conclusions Findings were notable for prominent language deficits, with preserved articulation, basic comprehension, and no evidence of visual agnosia. Her progression of symptoms, medical history, and test data were not consistent with a typical Alzheimer’s or vascular process, but were most consistent with lvPPA. Neurology consultation, MRI brain with volumetric analysis, and speech therapy were recommended.


Aphasiology ◽  
2014 ◽  
Vol 28 (8-9) ◽  
pp. 1004-1017 ◽  
Author(s):  
Joseph R. Duffy ◽  
Edythe A. Strand ◽  
Keith A. Josephs

2018 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Salime Jafari ◽  
Ahmad Reza Khatoonabadi ◽  
Maryam Noroozian ◽  
Azar Mehri ◽  
Hassan Ashayeri ◽  
...  

Neurology ◽  
2021 ◽  
Vol 96 (6) ◽  
pp. e916-e925
Author(s):  
M.-Marsel Mesulam ◽  
Christina Coventry ◽  
Alan Kuang ◽  
Eileen H. Bigio ◽  
Qinwen Mao ◽  
...  

ObjectiveTo determine whether memory is preserved longitudinally in primary progressive aphasia (PPA) associated with Alzheimer disease (AD) and to identify potential factors that maintain memory despite underlying neurofibrillary degeneration of mediotemporal memory areas.MethodsLongitudinal memory assessment was done in 17 patients with PPA with autopsy or biomarker evidence of AD (PPA-AD) and 14 patients with amnestic dementia of the Alzheimer type with AD at autopsy (DAT-AD).ResultsIn PPA-AD, episodic memory, tested with nonverbal items, was preserved at the initial testing and showed no decline at retesting 2.35 ± 0.78 years later, at which time symptoms had been present for 6.26 ± 2.21 years. In contrast, language functions declined significantly during the same period. In DAT-AD, both verbal memory and language declined with equal severity. Although imaging showed asymmetric left-sided mediotemporal atrophy in PPA-AD, autopsy revealed bilateral hippocampo-entorhinal neurofibrillary degeneration at Braak stages V and VI. Compared to DAT-AD, however, the PPA-AD group had lower incidence of APOE ε4 and of mediotemporal TAR DNA-binding protein 43 (TDP-43) pathology.ConclusionsMemory preservation in PPA is not just an incidental finding at onset but a core feature that persists for years despite the hippocampo-entorhinal AD neuropathology that is as severe as that of DAT-AD. Asymmetry of mediotemporal atrophy and a lesser impact of APOE ε4 and of TDP-43 on the integrity of memory circuitry may constitute some of the factors underlying this resilience. Our results also suggest that current controversies on memory in PPA-AD reflect inconsistencies in the diagnosis of logopenic PPA, the clinical variant most frequently associated with AD.ClinicalTrials.gov IdentifierNCT00537004 and NCT03371706.


2019 ◽  
Vol 15 (4) ◽  
pp. 527
Author(s):  
Hye Jin Jeong ◽  
Cindy W Yoon ◽  
Seongho Seo ◽  
Sang-Yoon Lee ◽  
Mee Kyung Suh ◽  
...  

2019 ◽  
Vol 15 ◽  
pp. P386-P386
Author(s):  
Young Noh ◽  
Hye Jin Jeong ◽  
Cindy W. Yoon ◽  
Kee Hyung Park ◽  
Kyoung-Min Lee ◽  
...  

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