Government-invested construction projects have their own characteristics, and effective management can be achieved only by adopting corresponding appropriate management approaches. The characteristics of government-invested construction project management and corresponding serious problems existed in present management are analyzed and summarized at first. Secondly, the countermeasures to above problems are put forward. Then, an information management system framework for government-invested project management is proposed on the basis of the foregoing work. This framework can realize the fusion of project information management system and E-government system and achieve the institutionalization, standardization, informatization and lifecycle management for government-invested project by means of multiple modernized information technologies and professional software. Finally, the development and application of the developed information system validate the effectiveness to promote the management level of government-invested construction project. The work involved in this paper can provide reference for the management of other similar construction projects.