Phosphatidylcholine for Steroid-Refractory Chronic Ulcerative Colitis

2007 ◽  
Vol 147 (9) ◽  
pp. 603 ◽  
Author(s):  
Wolfgang Stremmel ◽  
Robert Ehehalt ◽  
Frank Autschbach ◽  
Max Karner
Keyword(s):  
Ulcerative Colitis ◽  
Chronic Ulcerative Colitis ◽  
Steroid Refractory

scholarly journals Infliximab Salvage Therapy after Cyclosporine in an Acute Flare of Chronic Ulcerative Colitis

2003 ◽  
Vol 17 (3) ◽  
pp. 198-200 ◽  
Author(s):  
ECS Lam ◽  
RJ Bailey
Keyword(s):  
Ulcerative Colitis ◽  
Continuous Infusion ◽  
Chronic Ulcerative Colitis ◽  
Salvage Therapy ◽  
Low Dose ◽  
Initial Response ◽  
Dose Oral ◽  
History Of ◽  
Intravenous Steroids ◽  
Steroid Refractory

Although infliximab (Remicade, Schering Canada Inc, Quebec) therapy has been well studied in steroid refractory Crohn’s disease, its use remains controversial in chronic ulcerative colitis. A 24-year-old woman with a 14-year history of well controlled left sided ulcerative colitis presented with an acute flare. Clinical, endoscopic and biopsy evidence of an acute flare of ulcerative pancolitis were present. There was no response to intravenous steroids but improvement was seen after receiving 14 days of intravenous cyclosporine (4 mg/kg/day continuous infusion). The patient was discharged from hospital with azathioprine (2.5 mg/kg/day) and low dose oral cyclosporine (4 mg/kg/day). She presented with worsening symptoms seven days after discharge. Because of the patient’s unwillingness for surgery, she instead received two injections of infliximab 5 mg/kg at week 0 and week 2. An initial response occurred, but her clinical improvement was not durable. Colectomy was performed four weeks later. This is the first report of infliximab as a salvage therapy in an acute flare of chronic ulcerative colitis following failure of cyclosporine.

Life Histories of Patients With Chronic Ulcerative Colitis: A Review of 2,000 Cases

1950 ◽  
Vol 16 (1) ◽  
pp. 25-38 ◽  
Author(s):  
Wyman P. Sloan ◽  
F. Arnold Bargen ◽  
Robert P. Gage
Keyword(s):  
Ulcerative Colitis ◽  
Chronic Ulcerative Colitis ◽  
Life Histories

Chronic Ulcerative Colitis

1960 ◽  
Vol 39 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Arthur E. Lindner ◽  
Ronald C. King ◽  
Robert J. Bolt
Keyword(s):  
Ulcerative Colitis ◽  
Chronic Ulcerative Colitis
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