scholarly journals Molecular Modeling and Preliminary Clinical Data Suggesting Antiviral Activity for Chlorpheniramine (Chlorphenamine) Against COVID-19

Cureus ◽  
2022 ◽  
Author(s):  
Shaun D Black
Keyword(s):  
Molecular Modeling ◽  
Antiviral Activity ◽  
Clinical Data

Synthesis, molecular modeling and antiviral activity of novel 5-fluoro-1H-indole-2,3-dione 3-thiosemicarbazones

2020 ◽  
Vol 104 ◽  
pp. 104202
Author(s):  
Zekiye Şeyma Sevinçli ◽  
Gizem Nur Duran ◽  
Mehmet Özbil ◽  
Nilgün Karalı
Keyword(s):  
Molecular Modeling ◽  
Antiviral Activity

scholarly journals Molecular docking study of oligonucleotides with D-mannitol

2017 ◽  
Vol 15 (1) ◽  
pp. 64-68
Author(s):  
V. Shchodryi ◽  
D. Lozhko ◽  
Z. Tkachuk
Keyword(s):  
Molecular Docking ◽  
Molecular Modeling ◽  
Antiviral Activity ◽  
Software Package ◽  
Virus Entry ◽  
Docking Study ◽  
Binding Energies ◽  
Important Task ◽  
Molecular Docking Study ◽  
Hyperchem Software

Aim. Complex of yeast RNA and D-mannitol has a specific antiviral activity. This complex inhibits the neuraminidase and hemagglutinin activity of viruses such as influenza, parainfluenza and thus it blocks virus entry into the cell and his replication. So, nowadays, study of the interaction of this compound is an important task. Study interaction of the oligoribonucleotides and oligodesoxynucleotides with D mannitol molecule. Methods. Molecular modeling structure of oligoribonucleotides and oligodesoxynucleotides were done by using «Hyperchem» software package. The AutoDock program was used to perform accuracy molecular docking. Results. Were obtained binding energies of D-mannitol molecule with oligoribonucleotides and oligodesoxynucleotides. We have shown the possible connections between atoms of oligonucleotides and D-mannitol molecule. Conclusions. The modeling results should give more detailed information about nature of the oligonucleotides binding with a shugar alcohol D-mannitol.Keywords: molecular docking, oligonucleotides, D-mannitol, binding energies.

scholarly journals Synthesis, antiviral activity and molecular modeling of oxoquinoline derivatives

2009 ◽  
Vol 17 (15) ◽  
pp. 5476-5481 ◽  
Author(s):  
Fernanda da C. Santos ◽  
Paula Abreu ◽  
Helena C. Castro ◽  
Izabel C.P.P. Paixão ◽  
Claudio C. Cirne-Santos ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Antiviral Activity

Synthesis, Molecular Modeling, and Antiviral Activity of Novel Triazole Nucleosides and Their Analogs

2019 ◽  
Vol 89 (9) ◽  
pp. 1896-1904 ◽  
Author(s):  
N. A. A. Elkanzi ◽  
W. I. El-Sofany ◽  
S. T. Gaballah ◽  
A. M. Mohamed ◽  
O. Kutkat ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Antiviral Activity

Antiviral activity of amantadine: a review of laboratory and clinical data

1980 ◽  
Vol 11 (1) ◽  
pp. 181-262 ◽  
Author(s):  
John S. Oxford ◽  
Alan Galbraith
Keyword(s):  
Antiviral Activity ◽  
Clinical Data
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