myocardial infarction
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2022 ◽  
Vol 12 (4) ◽  
pp. 731-738
Zhitang Chang ◽  
Guotai Sheng ◽  
Yizhong Zhou ◽  
Zhiyong Wu ◽  
Guobo Xie ◽  

Based on the promotion of myocardial activity via endothelial progenitor cells (EPCs) subsequent to acute myocardial infarction (AMI), our research was designed to explore the influence of excessive HIF-1α expression in expanded EPCs (eEPCs) on promotion of the activity of left ventricle subsequent to MI. Isolation of EPCs from cord blood was performed before transduction with the help of retroviral vector with or without HIF-1α expression. Transplantation was performed subsequent to ligation of the left anterior descending coronary artery in mice. Ejection fraction (EF) of left ventricle was promoted via transplantation after 2 weeks. Excessive HIF-1α expression enhanced EF of left ventricle and decreased the extent of MI. It was revealed via functional studies that excessive HIF-1α expression enhanced proliferation of EPCs triggered by low oxygen concentration and suppressed cell death in the region of infarction. Moreover, markers of endothelium CD31, VEGF, and eNOS were upregulated. Transplantation of eEPCs with excessive HIF-1α expression in AMI can promote myocardial activities by increasing differentiation, generation of vessels, proliferation of eEPCs, and suppressing cell death. The above findings propose that regulation of EPCs via HIF-1α enhances the activity as well as mobilization of EPCs, indicating that reinforcement of expression of HIF-1α is beneficial for coronary heart disease.

2022 ◽  
Vol 204 ◽  
pp. 111975
Toyib Olaniyan ◽  
Lauren Pinault ◽  
Chi Li ◽  
Aaron van Donkelaar ◽  
Jun Meng ◽  

2022 ◽  
Vol 146 ◽  
pp. 112584
Maryam Tajabadi ◽  
Hanif Goran Orimi ◽  
Maryam Roya Ramzgouyan ◽  
Alireza Nemati ◽  
Niloofar Deravi ◽  

2022 ◽  
Vol 38 ◽  
pp. 100953
Yosuke Katayama ◽  
Akira Taruya ◽  
Manabu Kashiwagi ◽  
Yuichi Ozaki ◽  
Yasutsugu Shiono ◽  

2022 ◽  
Vol 163 ◽  
pp. 9-19
Xinrui Wang ◽  
Tina C. Wan ◽  
Amelia Lauth ◽  
Alexandra L. Purdy ◽  
Katherine R. Kulik ◽  

2022 ◽  
Vol 8 ◽  
Kate Liang ◽  
Eleni Nakou ◽  
Marco Giuseppe Del Buono ◽  
Rocco Antonio Montone ◽  
Domenico D'Amario ◽  

Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) accounts for 5–15% of all presentations of acute myocardial infarction. The absence of obstructive coronary disease may present a diagnostic dilemma and identifying the underlying etiology ensures appropriate management improving clinical outcomes. Cardiac magnetic resonance (CMR) imaging is a valuable, non-invasive diagnostic tool that can aide clinicians to build a differential diagnosis in patients with MINOCA, as well as identifying non-ischemic etiologies of myocardial injury (acute myocarditis, Takotsubo Syndrome, and other conditions). The role of CMR in suspected MINOCA is increasingly recognized as emphasized in both European and American clinical guidelines. In this paper we review the indications for CMR, the clinical value in the differential diagnosis of patients with suspected MINOCA, as well as its current limitations and future perspectives.

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