Mechanism(s) of Membrane Permeability Transition in Liver Mitochondria of Lamprey, Lampetra fluviatilis L. during Pre-spawning Starvation

2021 ◽  
pp. 105-129
Author(s):  
Elena A. Belyaeva
Keyword(s):  
Membrane Permeability ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Lampetra Fluviatilis ◽  
Membrane Permeability Transition

scholarly journals On the Mechanism(s) of Membrane Permeability Transition in Liver Mitochondria of Lamprey,Lampetra fluviatilis L.: Insights from Cadmium

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Elena A. Belyaeva ◽  
Larisa V. Emelyanova ◽  
Sergey M. Korotkov ◽  
Irina V. Brailovskaya ◽  
Margarita V. Savina
Keyword(s):  
Membrane Permeability ◽  
Cyclosporine A ◽  
Mitochondrial Permeability Transition Pore ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Nitrate Medium ◽  
Lampetra Fluviatilis ◽  
Mitochondrial Permeability

Previously we have shown that opening of the mitochondrial permeability transition pore in its low conductance state is the case in hepatocytes of the Baltic lamprey (Lampetra fluviatilis L.) during reversible metabolic depression taking place in the period of its prespawning migration when the exogenous feeding is switched off. The depression is observed in the last year of the lamprey life cycle and is conditioned by reversible mitochondrial dysfunction (mitochondrial uncoupling in winter and coupling in spring). To further elucidate the mechanism(s) of induction of the mitochondrial permeability transition pore in the lamprey liver, we used Cd2+and Ca2+plus Pias the pore inducers. We found that Ca2+plus Piinduced the high-amplitude swelling of the isolated “winter” mitochondria both in isotonic sucrose and ammonium nitrate medium while both low and high Cd2+did not produce the mitochondrial swelling in these media. Low Cd2+enhanced the inhibition of basal respiration rate of the “winter” mitochondria energized by NAD-dependent substrates whereas the same concentrations of the heavy metal evoked its partial stimulation on FAD-dependent substrates. The above changes produced by Cd2+or Ca2+plus Piin the “winter” mitochondria were only weakly (if so) sensitive to cyclosporine A (a potent pharmacological desensitizer of the nonselective pore) added alone and they were not sensitive to dithiothreitol (a dithiol reducing agent). Under monitoring of the transmembrane potential of the “spring” lamprey liver mitochondria, we revealed that Cd2+produced its decrease on both types of the respiratory substrates used that was strongly hampered by cyclosporine A, and the membrane potential was partially restored by dithiothreitol. The effects of different membrane permeability modulators on the lamprey liver mitochondria function and the seasonal changes in their action are discussed.

scholarly journals Hypothyroidism renders liver mitochondria resistant to the opening of membrane permeability transition pore

1998 ◽  
Vol 1407 (3) ◽  
pp. 243-248 ◽  
Author(s):  
Edmundo Chávez ◽  
Martha Franco ◽  
Horacio Reyes-Vivas ◽  
Cecilia Zazueta ◽  
Jorge Ramı́rez ◽  
...  
Keyword(s):  
Membrane Permeability ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Membrane Permeability Transition

Suramin inhibits respiration and induces membrane permeability transition in isolated rat liver mitochondria

Toxicology ◽  
2001 ◽  
Vol 169 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Celene F Bernardes ◽  
Marcia M Fagian ◽  
José R Meyer-Fernandes ◽  
Roger F Castilho ◽  
Anibal E Vercesi
Keyword(s):  
Membrane Permeability ◽  
Rat Liver ◽  
Permeability Transition ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Membrane Permeability Transition ◽  
Isolated Rat Liver ◽  
Isolated Rat
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