This is the supplementary document of R package regmedint that implements the extension of the regression-based causal mediation analysis first proposed by Valeri and VanderWeele (2013, 2015). It supports including effect measure modification by covariates (treatment-covariate and mediator-covariate product terms in mediator and outcome regression models), and also accommodates the original SAS macro and PROC CAUSALMED procedure in SAS when there is no effect measure modification.